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MetabolomicsFunctional Remodeling of iNKT Cells by Sulfatide-Reactive Type II NKT Cells Reprograms Alveolar Macrophages to Alleviate Lung Ischemia-Reperfusion Injury

Lung ischemia-reperfusion injury (LIRI) is a serious complication in critical clinical situations. Despite its importance, the specific role of type II natural killer T (NKT) cells in LIRI remains unclear. In this study, we establish a LIRI mouse model and demonstrate that sulfatide-reactive type...

2025-12-19 | MTBLS13533 | MetaboLights
TranscriptomicsImmunoproteasome dysfunction augments alternative polarization of alveolar macrophages
The proteasome is a central regulatory hub for intracellular signaling by degrading numerous signaling mediators. Immunoproteasomes are specialized types of proteasomes known to be involved in shaping adaptive immune responses, but their role for innate immune signaling is elusive. Here, we analyzed...
ORGANISM(S): Mus musculus 
2016-06-29 | E-GEOD-72000 | biostudies-arrayexpress
TranscriptomicsMicroarray studies on effect of Pneumocystis carinii infection on global gene expression in alveolar macrophages
With a filter of false-discovery rate less than 0.1 and fold change greater than 1.5, 115 genes were found to be up- and 137 were down-regulated in alveolar macrophages during Pneumocystis carinii infection. Total RNA samples from 4 each of normal, dexamethasone-treated, and Pneumocystis carinii-inf...
ORGANISM(S): Rattus norvegicus 
2010-04-12 | E-GEOD-20149 | biostudies-arrayexpress
TranscriptomicsCigarette smoking alters mRNA expression in human alveolar macrophages
Alveolar macrophages from never smokers and active smokers were isolated by bronchoalveolar lavage and gene expression was measured. Chronic cigarette smoke exposure, as occurs in smoker's lungs, leads to significant changes in gene expression. Of note, RNA was isolated immediately following bronch...
ORGANISM(S): Homo sapiens 
2012-10-02 | E-GEOD-34517 | biostudies-arrayexpress
TranscriptomicsData expression in alveolar macrophages induced by lipopolysaccharide in humans
Rationale: Lipopolysaccharide (LPS) is ubiquitous in the environment. Inhalation of LPS has been implicated in the pathogenesis and/or severity of several lung diseases, including pneumonia, chronic obstructive pulmonary disease and asthma. Alveolar macrophages are the main resident leukocytes expos...
ORGANISM(S): Homo sapiens 
2012-09-15 | E-GEOD-40885 | biostudies-arrayexpress
TranscriptomicsMouse GM-CSF-related alveolar macrophage genome-wide expression data
GM-CSF receptor-β deficient (Csf2rb–/– or KO) mice develop a lung disease identical to hereditary pulmonary alveolar proteinosis (hPAP) in humans with recessive CSF2RA or CSF2RB mutations that impair GM-CSF receptor function. We performed pulmonary macrophage transplantation (PMT) of bone marro...
ORGANISM(S): Mus musculus 
2014-10-01 | E-GEOD-60528 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human peripheral blood monocyte (MONO), human peripheral blood monocyte derived macrophages treated with M-CSF (MACRO)and primary alveolar macrophages (BAL)
In order to study the gene expression profiles of monocyte and macrophages, we collected three type of cells and performed pair-wised comparison. It includes human peripheral blood monocyte (MONO), human peripheral blood monocyte derived macrophages treated with M-CSF (MACRO)and primary alveolar mac...
ORGANISM(S): Homo sapiens 
2006-12-01 | E-MEXP-524 | biostudies-arrayexpress
TranscriptomicsATAC-sequencing of murine alveolar macrophages after IL-33 treatment
ATAC-sequencing of murine alveolar macrophages after 3 I.T. doses of PBS (control) or IL-33 treatment.
ORGANISM(S): Mus musculus 
2025-12-12 | E-MTAB-16048 | biostudies-arrayexpress
TranscriptomicsIRF4 CUT&RUN sequencing of murine alveolar macrophages after IL-33 treatment
CUT&RUN of IRF4 in murine alveolar macrophages after 3 I.T. doses of PBS (control) or IL-33 treatment.
ORGANISM(S): Mus musculus 
2025-12-12 | E-MTAB-16047 | biostudies-arrayexpress
TranscriptomicsGene expression pattern of alveolar macrophages of allergic asthmatics in comparison with control subjects
The implication of alveolar macrophages (AM) in asthma, a Th2 disease, has not been well characterized. Thus, the goal of this study is to better characterize AM phenotype of allergic asthmatic compared with normal subjects using genomic expression analyses. Microarray analyses were performed with A...
ORGANISM(S): Homo sapiens 
2010-07-29 | E-GEOD-22528 | biostudies-arrayexpress
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