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Trypomastigotes from Trypanosoma cruzi adhere to the extracellular matrix (ECM) in order to invade mammalian host cells. Incubation of trypomastigotes with ECM leads to a decrease of nitric oxide synthase (NOS) activity and associated post-translational modifications (PTMs). Herein, resin-assisted e...
ORGANISM(S): Trypanosoma cruzi 
2020-10-27 | PXD018275 | Pride
Trypanosoma cruzi, the etiological agent of Chagas’ disease, affects 8 million people predominantly living in socioeconomic underdeveloped areas. T. cruzi trypomastigotes (Ty), the classical infective stage, interact with the extracellular matrix (ECM), an obligatory step before invasion of almost a...
ORGANISM(S): Trypanosoma cruzi Dm28c 
2019-01-07 | PXD010970 | Pride
C57BL/6 WT mice were infected with 1x10^6 P. brasiliensis yeasts. After 8 weeks and 12 weeks of infection the animals were euthanized and the granulomatous lesions were recovered. Then, the animals cells were lysed with distilled water and the yeast cell recovered. Once isolated, the yeasts proteins...
ORGANISM(S): Paracoccidioides brasiliensis (strain Pb18) 
2023-10-23 | PXD040826 | Pride
C57BL/6 WT mice were infected with 1x10^6 P. brasiliensis yeasts. After 8 weeks and 12 weeks of infection the animals were euthanized and the granulomatous lesions were recovered. Then, the yeasts were recovered and cultivated in a rich medium. After cultivation the yeasts proteins were extracted, d...
ORGANISM(S): Paracoccidioides brasiliensis (strain Pb18) 
2023-10-23 | PXD040829 | Pride
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