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TranscriptomicsCD40-mediated amplification of local immunity by keratinocytes in impaired by HPV
The interaction between the transmembrane glycoprotein surface receptor CD40 expressed by skin keratinocytes (KCs) and its T cell-expressed ligand CD154 was suggested to exacerbate inflammatory skin diseases. However, the full spectrum of CD40-mediated effects by KCs underlying this observation is u...
ORGANISM(S): Homo sapiens 
2015-10-26 | E-GEOD-54181 | biostudies-arrayexpress
TranscriptomicsInferring transcriptional and microRNA-mediated regulatory programs in glioblastoma
Large-scale cancer genomics projects are profiling hundreds of tumors at multiple molecular layers, including copy number, mRNA and miRNA expression, but the mechanistic relationships between these layers are often excluded from computational models. We developed a supervised learning framework for...
ORGANISM(S): Homo sapiens 
2011-10-11 | E-GEOD-32876 | biostudies-arrayexpress
TranscriptomicsZebularine effect on mouse embryonic stem cells manifested as cardiod-myogenic potential: testable hypothesis generation using microarray data
Lineage commitment during Embryonic Stem Cells (ESCs) differentiation is controlled not only by a gamut of transcription factors but also by epigenetic events, mainly histone deacetylation and promoter DNA methylation. Moreover, the DNA demethylation agent 5′-Aza-2′-deoxycytidine (AzadC) has been wi...
ORGANISM(S): Mus musculus 
2011-05-05 | E-GEOD-29072 | biostudies-arrayexpress
TranscriptomicsFOXA1 actively represses the molecular phenotype of basal breast cancers.
Breast cancer is a heterogeneous disease comprised of at least five major subtypes. Luminal subtype tumors confer a more favourable patient prognosis, which is in part, attributed to the Estrogen Receptor-alpha (ER) positivity and anti-hormone responsiveness of these tumors. Expression of the forkhe...
ORGANISM(S): Homo sapiens 
2012-03-09 | E-GEOD-31003 | biostudies-arrayexpress
TranscriptomicsIdentification of global alteration of translational regulation in glioma in vivo
Post-transcriptional regulation of gene expression contributes to the protein output of a cell, however, methods for measuring translational regulation in complex in vivo systems are lacking. Here, we describe a sensitive method for measuring translational regulation in defined cell populations from...
ORGANISM(S): Mus musculus 
2012-12-31 | E-GEOD-38591 | biostudies-arrayexpress
TranscriptomicsTranscriptomics of vitamin D treatment effects in Mycobacterium tuberculosis-infected THP-1 cells
Previous reports have shown low vitamin D serum levels and polymorphisms in the vitamin D receptor (VDR) to be associated with increased risk for TB. Given that 1?,25-dihydroxyvitamin D3 has a role in lipid metabolism control, we tested whether the link between 1?,25-dihydroxyvitamin D3 and tubercul...
ORGANISM(S): Homo sapiens 
2014-07-01 | E-GEOD-57028 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human normal breast epithelium and stroma from reduction and I.D.C. cases
Histologically normal breast epithelium and stroma were laser capture microdissected from breast reduction specimens and from specimens of invasive ductal carcinoma. The objective of the study was to compare normal reduction tissues to tissues adjacent to I.D.C. to determine whether adjacent normal...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-4823 | biostudies-arrayexpress
Transcriptomicsdyrk1a
Transcription profiling of transgenic down syndrome mouse model to show the role of DYRK1A gene. The molecular mechanisms that lead to the cognitive defects characteristic of Down syndrome (DS), the most frequent cause of mental retardation, have remained elusive. Here we use a transgenic DS mouse m...
ORGANISM(S): Mus musculus 
2010-05-05 | E-GEOD-14072 | biostudies-arrayexpress
UnknownGlobal hospital-based disease management of acute diverticulitis: a prospective, international cohort study.
Not available
S-EPMC12512976 | biostudies-literature
UnknownClopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA.
Not available
S-EPMC6193486 | biostudies-literature
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