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TranscriptomicsHif1α down-regulation is associated with transposition of great arteries in mice treated with a RA antagonist
Aims: Congenital heart defect (CHD) account for 25% of all human congenital abnormalities. Very few CHD-causing genes have been identified so far; so, to discover further genes we performed a global transcriptome analysis in mouse models of CHD. Methods and results: By the use of a retinoic acid com...
ORGANISM(S): Mus musculus 
2010-09-20 | E-GEOD-19012 | biostudies-arrayexpress
TranscriptomicsSelective transcriptional regulation by Myc in cellular growth control and lymphomagenesis [RNA-Seq]
The c-myc proto-oncogene product, Myc, is a transcription factor that binds thousands of genomic loci. Recent work suggested that rather than up- and down-regulating selected groups of genes, Myc targets all active promoters and enhancers in the genome (a phenomenon termed "invasion") and ...
ORGANISM(S): Mus musculus 
2014-07-07 | E-GEOD-51008 | biostudies-arrayexpress
TranscriptomicsmicroRNA and aging
The critical role of the endothelium in governing vascular, tissues homeostasis and pathological processes is increasingly recognized (Deanfield et al., 2007). Cellular senescence of endothelial cells has been proposed to be involved in endothelial dysfunction and atherogenesis (Minamino T et al., 2...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-14912 | biostudies-arrayexpress
UnknownLOX-1 and Its Splice Variants: A New Challenge for Atherosclerosis and Cancer-Targeted Therapies.
Not available
S-EPMC5343826 | biostudies-literature
UnknownThe human rs1050286 polymorphism alters LOX-1 expression through modifying miR-24 binding.
Not available
S-EPMC4717858 | biostudies-literature
UnknownHif1α down-regulation is associated with transposition of great arteries in mice treated with a retinoic acid antagonist.
Not available
S-EPMC2996993 | biostudies-literature
UnknownVertebral fractures and bone health in patients with chronic non-bacterial osteomyelitis at disease onset: insights from the monocentric CAMELOT cohort.
Not available
S-EPMC12534819 | biostudies-literature
GenomicsSelective transcriptional regulation by Myc in cellular growth control and lymphomagenesis [DNAse-Seq]
The c-myc proto-oncogene product, Myc, is a transcription factor that binds thousands of genomic loci. Recent work suggested that rather than up- and down-regulating selected groups of genes, Myc targets all active promoters and enhancers in the genome (a phenomenon termed "invasion") and ...
ORGANISM(S): Mus musculus 
2014-07-07 | E-GEOD-50823 | biostudies-arrayexpress
UnknownAn RNA-seq study in Friedreich ataxia patients identified hsa-miR-148a-3p as a putative prognostic biomarker of the disease.
Not available
S-EPMC11110315 | biostudies-literature
TranscriptomicsPin1 is required for sustained B cell proliferation upon oncogenic activation of Myc
The c-myc proto-oncogene is activated by translocation in Burkitt's lymphoma and substitutions in codon 58 stabilize the Myc protein or augment its oncogenic potential. In wild-type Myc, phosphorylation of Ser 62 and Thr 58 provide a landing pad for the peptidyl prolyl-isomerase Pin1, which in turn ...
ORGANISM(S): Mus musculus 
2016-06-14 | E-GEOD-77482 | biostudies-arrayexpress
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