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Plerixafor (AMD3100) and G-CSF mobilize peripheral blood stem cells (PBSCs) by different mechanisms. A rhesus macaque model was used to compare plerixafor and G-CSF-mobilized CD34+ cells. Three PBSC concentrates were collected from 3 macaques treated with G-CSF, plerixafor, or plerixafor plus G-CSF....
ORGANISM(S): Macaca mulatta 
Mobilized-peripheral blood hematopoietic stem cells (HSCs) have been used for transplantation, immunotherapy, and cardiovascular regenerative medicine. Agents used for HPC mobilization include G-CSF and the CXCR4 inhibitor AMD3100. The HSCs cells mobilized by each agent may contain different subtype...
ORGANISM(S): Homo sapiens 
Chronic stress is a common cause of hair loss, involving inflammatory responses and changes in cellular signaling pathways. This study explores the mechanism of action of the SDF-1/CXCR4 signaling axis in chronic stress-induced hair loss. The research indicates that SDF-1 promotes hair follicle grow...
ORGANISM(S): Mus Musculus 
2024-10-18 | PXD056932 |
Mobilized-peripheral blood hematopoietic stem cells (HSCs) have been used for transplantation, immunotherapy, and cardiovascular regenerative medicine. Agents used for HPC mobilization include G-CSF and the CXCR4 inhibitor AMD3100. The HSCs cells mobilized by each agent may contain different subtype...
ORGANISM(S): Homo sapiens 
Mobilized-peripheral blood hematopoietic stem cells (HSCs) have been used for transplantation, immunotherapy, and cardiovascular regenerative medicine. Agents used for HPC mobilization include G-CSF and the CXCR4 inhibitor AMD3100. The HSCs cells mobilized by each agent may contain different subtype...
ORGANISM(S): Human herpesvirus 4 
RNA sequencing of AMD3100-treated E14 embryonic submandibular glands (eSMGs)
Variation of mRNA and lncRNA expression after using AMD3100 in rat chronic allograft nephropathy model.
In order to elucidate the relationship between CXC chemokine receptor 4 (CXCR4) and embryonic organogenesis, we performed 3' mRNA-seq on control and AMD3100-treated eSMGs.
ORGANISM(S): Mus musculus 
2021-01-27 | GSE160735 | GEO
Successful gene therapy for β-thalassemia requires optimal numbers of autologous gene-transduced hematopoietic progenitors stem cells (HPSC) with high repopulating capacity and mobilization is the optimal approach for achieving this goal. We performed a clinical study to investigate safety and effi...
ORGANISM(S): Homo sapiens 
To investigate the variation of mRNA and lncRNA expression after using AMD3100 in rat chronic allograft nephropathy model (CAN) model, we have employed mRNA and lncRNA microarray expression profiling as a discovery platform to identify genes with the potential. CAN rat models were established using ...
ORGANISM(S): Rattus norvegicus 
2018-05-08 | GSE114088 | GEO
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