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MetabolomicsEffect of Odc knockout on amino acid homeostasis of Eu-Myc Lymphomas
Not available
ORGANISM(S): Mus musculus 
ST000461 | MetabolomicsWorkbench
MetabolomicsMetabolomics Analysis Identifies Glutamic acid and Cystine imbalances in COVID-19 Patients Without Comorbid Conditions. Implications on Redox Homeostasis and COVID-19 Pathophysiology

It is well known that the presence of comorbidities and age-related health issues may hide biochemical and metabolic features triggered by SARS-CoV-2 infection and other diseases associated to hypoxia, as they are by themselves chronic inflammatory conditions that may potentially disturb metaboli...

2024-08-26 | MTBLS5011 | MetaboLights
TranscriptomicsLet-7 coordinately suppresses components of the amino acid sensing pathway to induce autophagy
Macroautophagy (hereafter autophagy) is the major pathway by which macromolecules and organelles are degraded. Autophagy is regulated by the mTOR signaling pathway, which is the focal point for integration of metabolic information, with mTORC1 playing a central role in balancing biosynthesis and cat...
ORGANISM(S): Mus musculus 
2015-08-03 | E-GEOD-60452 | biostudies-arrayexpress
MetabolomicsHomeostasis of the biosynthetic E. coli metabolome
Metabolite concentrations vary across conditions and such metabolome changes are relevant for metabolic and gene regulation. Here, we used LC-MS/MS to explore metabolite concentration changes in Escherichia coli. We measured 101 primary metabolites in 19 experimental conditions that include v...
2022-11-02 | MTBLS4249 | MetaboLights
MetabolomicsA Plastoglobuli-Localized Enzyme Links Phenylalanine Biosynthesis to Translational Homeostasis in Maize
Aromatic amino acids are essential precursors for numerous plant metabolites, with phenylalanine (Phe) forming the basis of the phenylpropanoid pathway. Here, we reveal a critical mechanism for Phe biosynthesis in maize, demonstrating that all seven arogenate dehydratases (ADTs) are specifically loc...
2026-06-25 | MTBLS14852 | MetaboLights
TranscriptomicsIsp7 is a novel regulator of amino acid uptake in the TOR signaling pathway
We show that the sensitivity of tsc mutant cells to rapamycin is mediated by TORC1 and can be suppressed by overexpression of the 2-oxoglutarate-Fe(II) dependent oxygenase, Isp7. We show that Isp7 is a novel regulator of amino acids uptake that acts via regulation of gene expression, both upstream a...
ORGANISM(S): Schizosaccharomyces pombe 
2014-02-05 | E-GEOD-52759 | biostudies-arrayexpress
MetabolomicsPlasma 1H-NMR metabolic and amino acid profiles of newborn piglets from two lines divergently selected for residual feed intake

Together with environmental factors, physiological maturity at birth is a major determinant for neonatal survival and postnatal development in mammalian species. Maturity at birth is the outcome of complex mechanisms of intra-uterine development and maturation during the end of gestation. In pig ...

2023-02-16 | MTBLS2137 | MetaboLights
ProteomicsInhibition of L-type amino acid transporter 1 induces disruption of cancer amino acid homeostasis with altered cellular signals
This study characterized the changes of phosphorylation signaling cascades induced by LAT1 inhibition in three cell lines of biliary tract cancer treated with LAT1 specific inhibitor JPH203 for 15 and 30 min. Immobilized metal affinity chromatography and liquid chromatography-tandem mass spectrometr...
ORGANISM(S): Homo Sapiens (human) 
2023-05-24 | PXD034276 | JPOST Repository
MetabolomicsResting natural killer cell homeostasis relies on tryptophan/NAD+ metabolism and HIF-1α

Natural killer (NK) cells are forced to cope with different oxygen environments even under resting conditions. The adaptation to low oxygen is regulated by oxygen-sensitive transcription factors, the hypoxia-inducible factors (HIFs). The function of HIFs for NK cell activation and metabolic rewir...

2023-06-01 | MTBLS6863 | MetaboLights
MetabolomicsLactiplantibacillus plantarum PS128 restores microbiota-driven polyamine homeostasis to alleviate autism-like behaviors in Fmr1 knockout mice

Background Autism spectrum disorder (ASD) is biologically heterogeneous and has limited mechanism-informed interventions targeting core behavioral symptoms. Emerging evidence suggests that gut microbial metabolism shapes neurobehavioral outcomes, yet the specific metabolic pathwa...

2026-02-06 | MTBLS13859 | MetaboLights
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