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MetabolomicsAmino Acid levels in preB cells under starvation
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ORGANISM(S): Mus musculus 
ST000251 | MetabolomicsWorkbench
MetabolomicsMetabolomic Analysis of Fission Yeast at the Onset of Nitrogen Starvation
Microorganisms naturally respond to changes in nutritional conditions by adjusting their morphology and physiology. The cellular response of the fission yeast S. pombe to nitrogen starvation has been extensively studied. Here, we report time course metabolomic analysis during one hour immediately af...
2013-11-26 | MTBLS67 | MetaboLights
MetabolomicsArginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction
Defective arginine synthesis, due to the silencing of argininosuccinate synthase 1 (ASS1), is a common metabolic vulnerability in cancer, known as arginine auxotrophy. Understanding how arginine depletion kills arginine-auxotrophic cancer cells will facilitate the development of anti-cancer therapeu...
2019-11-07 | MTBLS745 | MetaboLights
MetabolomicsOrganotypic microfluidic breast cancer model reveals starvation-induced spatial-temporal metabolic adaptations
BACKGROUND: Ductal carcinoma in situ (DCIS) is the earliest stage of breast cancer. During DCIS, tumor cells remain inside the mammary duct, growing under a microenvironment characterized by hypoxia, nutrient starvation, and waste product accumulation; this harsh microenvironment promotes genomic in...
2019-02-08 | MTBLS669 | MetaboLights
MetabolomicsSpecific biomarkers for stochastic division patterns and starvation-induced quiescence under limited glucose levels in fission yeast
Glucose as a source of energy is centrally important to our understanding of life. We investigated the cell division-quiescence behavior of the fission yeast Schizosaccharomyces pombe under a wide range of glucose concentrations (0-111 mM). The mode of S. pombe cell division under a microfluidic per...
2017-07-06 | MTBLS316 | MetaboLights
TranscriptomicsTranscription profiling by array of yeast gcn2, gcn4 and gln3 deletion mutants treated with rapamycin or 3-amino-1,2,4-triazole (3-AT)
Two nutrient sensing and regulatory pathways, the general amino acid control (GAAC) and the target of rapamycin (TOR), control yeast growth and metabolism in response to changes in nutrient availability. Starvation for amino acids activates the GAAC pathway, involving Gcn2p phosphorylation of eIF2 ...
ORGANISM(S): Saccharomyces cerevisiae 
2010-03-07 | E-GEOD-15254 | biostudies-arrayexpress
TranscriptomicsE. coli Isoleucine starvation and stringent response network
Transcription profiling of wild type, relA-, and relA-spoT-, crp-, dksA-, rpoS-, lrp- mutant strains of E. coli starved for isoleucine Bacteria comprehensively reorganize their global gene expression when faced with nutrient exhaustion. In Escherichia coli and other free-living bacteria, the alarmo...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2008-04-08 | E-GEOD-11087 | biostudies-arrayexpress
TranscriptomicsAmpliSeq Data of WT and SLC38A10 knockout primary cortex cells in amino acid starvation and refed conditions
Samples-WT Basal condition primary cortex cells; WT B27 Starved-Primary cortex cells starved overnight without B27 supplement media. WT AA Starved-Primary cortex cell starved without amino acid for 2 hours. WT AA Refed-Primary cortex cell refed for 1 hour after amino acid starvation. KO Basal-SLC38 ...
ORGANISM(S): Mus musculus 
2021-06-03 | E-MTAB-10413 | biostudies-arrayexpress
TranscriptomicsResponse of Lactococcus lactis to isoleucine starvation
For the first time in Lactococcus lactis, amino acid starvation response was characterized. The natural imposition of isoleucine starvation, by its consumption during growth, associated to transcript profiling, allowed defining exhaustively this stress stimulon. It consisted of a general induction o...
ORGANISM(S): Lactococcus lactis 
2010-06-25 | E-GEOD-4872 | biostudies-arrayexpress
ProteomicsCodon-specific ribosome stalling reshapes translational dynamics during branched-chain amino acid starvation
This study investigates the immediate effects of single, double, and triple branched-chain amino acid (BCAA) deprivation on translational dynamics in NIH3T3 cells. Using a multi-omics approach combining RNA-seq, ribosome profiling (Ribo-seq), quantitative proteomics, and tRNA charging assays, we sys...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-13 | PXD067949 | Pride
Proteomics Elongation bottleneck Nutrient stress response Mass spectrometry Nih3t3 cells Ribosome profiling Amino acid starvation Translation regulation Trna charging Codon-specific stalling 
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