E. coli Isoleucine starvation and stringent response network

ABSTRACT: Transcription profiling of wild type, relA-, and relA-spoT-, crp-, dksA-, rpoS-, lrp- mutant strains of E. coli starved for isoleucine Bacteria comprehensively reorganize their global gene expression when faced with nutrient exhaustion. In Escherichia coli and other free-living bacteria, the alarmone ppGpp facilitates this massive response by directly or indirectly coordinating the down-regulation of genes of the translation apparatus, and the induction of biosynthetic genes and the general stress response. Such a large reorientation likely requires the cooperative activities of many different genetic regulators, yet the structure of the transcription network below the level of ppGpp remains poorly defined. Using isoleucine starvation as an experimental model system for amino acid starv

ORGANISM(S): Escherichia coli str. K-12 substr. MG1655

SUBMITTER: Tyrrell Conway 

PROVIDER: E-GEOD-11087 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress