Role of mRNA stability during bacterial adaptation

ABSTRACT: Bacterial adaptation involves extensive cellular reorganization. In particular, growth rate adjustments are associated with substantial modifications of gene expression and mRNA abundance. In this work we aimed to assess the role of mRNA degradation during such variations. A genome-wide transcriptomic-based method was used to determine mRNA half-lives. The model bacterium Lactococcus lactis was used and five growth rates were studied in continuous cultures under isoleucine-limitation and in batch cultures during the adaptation to the isoleucine starvation. During continuous isoleucine-limited growth, the mRNAs of different genes had different half-lives. The stability of most of the transcripts was not constant, and increased as the growth rate decreased. This half-life diversity was a

ORGANISM(S): Lactococcus lactis

SUBMITTER: Muriel Cocaign-Bousquet 

PROVIDER: E-GEOD-43875 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress