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ProteomicsThe anti-MRSA compound KCR inhibits protein synthesis in Staphylococcus aureus
S aureus was treated in triplicate with 3-O-alpha-L-(2",3"-di-p-coumaroyl)rhamnoside (KCR), oxacillin or vehicle and quantitative proteomic analysis was carried out using isobaric tags and mass spectrometry. 1190 proteins were identified and 552 were affected by KCR (q<0.01). Ontology analysis ide...
ORGANISM(S): Staphylococcus Aureus (ncbitaxon:1280) 
MSV000084282 | MassIVE
TranscriptomicsRibo-seq of HEK293T overexpressing WT and G240R GARS
Charcot-Marie-Tooth (CMT) disease can be caused by mutations in Aminoacyl-tRNA-Synthetases, including G240R mutation in Glycyl-tRNA-Synthetase (GARS). Ribo-seq generates snapshots of translating ribosomes on mRNA and therefore allows analysis of ribosome pausing mRNA. Here we performed Ribo-seq on l...
ORGANISM(S): Homo sapiens 
2021-09-14 | E-MTAB-10342 | biostudies-arrayexpress
UnknownContribution of upregulated aminoacyl-tRNA biosynthesis to metabolic dysregulation in gastric cancer.
Not available
S-EPMC9292402 | biostudies-literature
TranscriptomicsSelective control of metabolism by the GCN2 eIF2 kinase pathway in Saccharomyces cerevisiae
When eukaryotic cells are deprived of amino acids, uncharged tRNAs accumulate and activate the conserved GCN2 protein kinase. We examine how yeast growth and tRNA charging or aminoacylation is affected during amino acid depletion in the presence and absence of GCN2. tRNA charging is measured using ...
ORGANISM(S): Saccharomyces cerevisiae 
2010-08-01 | E-GEOD-22452 | biostudies-arrayexpress
GenomicsComprehensive characterization of mRNAs associated with yeast cytosolic aminoacyl-tRNA synthetases
Comprehensive characterization of mRNAs associated with yeast cytosolic aminoacyl-tRNA synthetases
PRJEB44410 | ENA
UnknownAn aminoacyl-tRNA synthetase that specifically activates pyrrolysine.
Not available
S-EPMC515082 | biostudies-literature
UnknownNatural Trojan horse inhibitors of aminoacyl-tRNA synthetases.
Not available
S-EPMC8323819 | biostudies-literature
ProteomicsIn vitro synthesis of 32 translation-factor proteins from a single template reveals impaired ribosomal processivity
The Protein synthesis Using Recombinant Elements (PURE) system enables transcription and translation of a DNA template from purified components. Therefore, the PURE system-catalyzed generation of RNAs and proteins constituting the PURE system itself represents a major challenge toward a self-replica...
ORGANISM(S): Escherichia Coli 
2021-09-06 | PXD020877 | panorama
ProteomicsRepurposing chloramphenicol acetyltransferase for a robust and efficient designer ester biosynthesis platform
Repurposing chloramphenicol acetyltransferase for a robust and efficient designer ester biosynthesis platform
ORGANISM(S): Clostridium Thermocellum Dsm 1313 (ncbitaxon:637887) Hungateiclostridium Thermocellum (ncbitaxon:1515) 
MSV000086201 | MassIVE
ProteomicsA methyltransferase-independent role for METTL1 in tRNA aminoacylation and oncogenic transformation
Data supporting the manuscript: A methyltransferase-independent role for METTL1 in tRNA aminoacylation and oncogenic transformation
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2024-11-05 | MSV000096296 | MassIVE
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