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MetabolomicsHydrolyzing NAD to NMN and AMP by SelO is required for mitochondria homeostasis

The regulation of mitochondrial nicotinamide adenine dinucleotide (mNAD) is crucial for numerous life processes. However, until now, no metabolic reaction responsible for downregulating mNAD has been identified. Through in silico screening of potential NAD-binding proteins, we discovered a previo...

2026-01-07 | MTBLS13624 | MetaboLights
TranscriptomicsHepatic Gene Expression Profiling of 5'AMP Induced Hypometabolism in Mice
Mice injected IP with 5'-AMP enter a hypometabolic state that is an induced hybernation (AIHM). Recovery from this AIHM is marked by reverse flip (RF) behavior Illumina arrays were used to profile control, AIHM and RF aminals in RNA prepared from the liver. Animals were injected with vehicle or 0.5 ...
ORGANISM(S): Mus musculus 
2012-06-19 | E-GEOD-23975 | biostudies-arrayexpress
TranscriptomicsRole of the AMP deaminase Amd1p in purines interconversion in Saccharomyces cerevisiae
In this work, we show that under specific conditions, defect in AMP deaminase activity strongly impairs yeast cell growth and we establish that AMP deaminase is required for correct balance between adenylic and guanylic nucleotides. Study of the Amd1p homologs, Yjl070p and Ybr284p, reveals that over...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-20 | E-GEOD-9557 | biostudies-arrayexpress
TranscriptomicsThe transcription factor cyclic AMP–responsive element–binding protein H regulates triglyceride metabolism
Here we report that the transcription factor cyclic AMP–responsive element–binding protein H (CREB-H, encoded by CREB3L3) is required for the maintenance of normal plasma triglyceride concentrations. CREB-H–deficient mice showed hypertriglyceridemia secondary to inefficient triglyceride clearance ca...
ORGANISM(S): Mus musculus 
2011-06-04 | E-GEOD-29643 | biostudies-arrayexpress
GenomicsSalinisphaera sp. SPP-AMP-43
Salinisphaera sp. SPP-AMP-43 Genome sequencing
PRJNA1076675 | ENA
GenomicsHaladaptatus sp. SPP-AMP-3
Haladaptatus sp. SPP-AMP-3 Genome sequencing
PRJNA1076672 | ENA
ProteomicsProteomics Analysis of the Mechanism of AMP-17 against Candida albicans
Candida albicans is the most common human fungal pathogen in immunocompromised individuals. With the emergence of clinical fungal resistance, there is an urgent demand to develop novel antifungal agents. The antibacterial peptide (AMP) is an important component in the innate immune system and has a ...
ORGANISM(S): Candida albicans (Yeast) 
2019-10-23 | PXD015469 | Pride
Candida albicans Amp-17 Antimicrobial peptides Proteomic Tmt- labeling Mechanism 
TranscriptomicsEffect of AMPK activation by AICAR on MA-10 Leydig cell transcriptome
Steroid hormones regulate essential physiological processes and inadequate levels are associated with various pathological conditions. In testosterone-producing Leydig cells, steroidogenesis is strongly stimulated by LH via its receptor leading to increased cAMP production and expression of the ster...
ORGANISM(S): Mus musculus 
2014-08-19 | E-GEOD-50118 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human primary foreskin fibroblasts following FCCP, oligomycin or AMP treatment
FCCP, Oligomycin and AMP lead to mitochondrial dysfunction. Here the influence of FCCP, Oligomycin and AMP on the transcriptome of PFF is examined.
ORGANISM(S): Homo sapiens 
2010-07-30 | E-MEXP-2285 | biostudies-arrayexpress
GenomicsWhole Genome Sequencing of PHACS AMP Cohort
Whole Genome Sequencing of PHACS AMP Cohort
PRJNA671431 | ENA
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