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MetabolomicsEnergy-stress-mediated AMPK activation inhibits ferroptosis

Energy stress depletes ATP and induces cell death. Here we identify an unexpected inhibitory role of energy stress on ferroptosis, a form of regulated cell death induced by iron-dependent lipid peroxidation. We found that ferroptotic cell death and lipid peroxidation can be inhibited by treatment...

2023-01-31 | MTBLS1399 | MetaboLights
TranscriptomicsEffect of AMPK activation by AICAR on MA-10 Leydig cell transcriptome
Steroid hormones regulate essential physiological processes and inadequate levels are associated with various pathological conditions. In testosterone-producing Leydig cells, steroidogenesis is strongly stimulated by LH via its receptor leading to increased cAMP production and expression of the ster...
ORGANISM(S): Mus musculus 
2014-08-19 | E-GEOD-50118 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse skeletal muscle of AMP-activated protein kinase gamma3 R225Q transgenic versus knock-out
Analysis of AMPK gamma3-dependent transcriptional responses by analyzing global gene expression in the white portion of the gastrocnemius muscle in AMPK gamma3 knock-out mice and corresponding wild type littermates.
ORGANISM(S): Mus musculus 
2007-12-14 | E-GEOD-4063 | biostudies-arrayexpress
GenomicsThe yeast AMP-activated protein kinase Snf1p phosphorylates the inositol polyphosphate kinase Kcs1p
The yeast AMP-activated protein kinase Snf1p phosphorylates the inositol polyphosphate kinase Kcs1p
PRJNA1034156 | ENA
GenomicsBiosacetalin 1,1-Diethoxyethane enhances aerobic respiration via activation of AMP-activated protein kinase
Biosacetalin 1,1-Diethoxyethane enhances aerobic respiration via activation of AMP-activated protein kinase
PRJNA1425579 | ENA
TranscriptomicsActivated AMPK and prostaglandins are involved in the response to conjugated linoleic acid and are sufficient to cause lipid reductions in adipocytes
Activated AMPK and prostaglandins are involved in the response to conjugated linoleic acid and are sufficient to cause lipid reductions in adipocytes. Trans-10, cis-12 conjugated linoleic acid (t10c12 CLA) reduces triglyceride levels in adipocytes. AMP-activated protein kinase (AMPK) was recently de...
ORGANISM(S): Mus musculus 
2010-08-10 | E-GEOD-17404 | biostudies-arrayexpress
TranscriptomicsExpression data of beta-subunit of Snf1 kinase in yeast Saccharomyces cerevisiae
The conserved Snf1/AMPK (AMP-activated protein Kinase) family is one of the central components in nutrient sensing and regulation of carbon metabolism in eukaryotes. It is also involved in several other processes such as stress resistance, invasive growth and ageing. Snf1 kinase is composed of a cat...
ORGANISM(S): Saccharomyces cerevisiae 
2010-05-27 | E-GEOD-20591 | biostudies-arrayexpress
TranscriptomicsConjugated linoleic acid activates AMPK and reduces adiposity more effectively when used with metformin
Trans-10, cis-12 conjugated linoleic acid (t10c12 CLA) causes dramatic reductions in white adipose tissue in mice but has had limited effectiveness in humans. Determination of the signaling pathways involved may lead to better regulation of adiposity. T10c12 CLA was found to activate AMP-activating...
ORGANISM(S): Mus musculus 
2009-11-01 | E-GEOD-14888 | biostudies-arrayexpress
ProteomicsQuantitative In Vivo Proteomics of Metformin Response in Liver Reveals AMPK-Dependent and -Independent Signaling Networks
Metformin is the front-line treatment for type 2 diabetes worldwide. It acts via effects on glucose and lipid metabolism in metabolic tissues, leading to enhanced insulin sensitivity. Despite significant effort, the molecular basis for metformin response remains poorly understood, with a limited nu...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2019-10-07 | MSV000084429 | MassIVE
GenomicsProtein Kinase AMP-Activated Catalytic Subunit Alpha 1 (PRKAA1) knockdown effect on the transcriptome of primary human acute myeloid leukemia (AML) cells
Protein Kinase AMP-Activated Catalytic Subunit Alpha 1 (PRKAA1) knockdown effect on the transcriptome of primary human acute myeloid leukemia (AML) cells
PRJNA464341 | ENA
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