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MetabolomicsUntargeted metabolomics to understand the basis of phenotypic differences in amphotericin B-resistant Leishmania parasites

BACKGROUND: Protozoan Leishmania parasites are responsible for a range of clinical infections that represent a substantial challenge for global health. Amphotericin B (AmB) is increasingly used to treat Leishmania infection, so understanding the potential for resistance to this d...

2019-09-26 | MTBLS1167 | MetaboLights
MetabolomicsAmphotericin B resistance in Leishmania mexicana: Alterations to sterol metabolism, lipid transport and oxidative stress response

Amphotericin B is increasingly used in treatment of leishmaniasis. Here, fourteen independent lines of Leishmania mexicana and one L. infantum line were selected for resistance to either amphotericin B or the related polyene antimicrobial, nystatin. Sterol profiling revealed tha...

2022-09-22 | MTBLS2744 | MetaboLights
TranscriptomicsEffect of amphotericin B on Aspergillus fumigatus
Amphotericin B (AMB) is the most widely used polyene antifungal drug for the treatment of systemic fungal infections including invasive aspergillosis. We aimed to understand molecular targets of AMB in Aspergillus fumigatus (Afu) by genomic approaches. Amphotericin B (AMB) is the most widely used p...
ORGANISM(S): Aspergillus fumigatus 
2010-05-26 | E-GEOD-10505 | biostudies-arrayexpress
no omics definedTranscription profiling of Candida albicans biofilm exposed to amphotericin B, fluconazole or two concentrations of caspofungin
30h of growth biofilms in microfermentors were exposed to caspofungin 0.5 µg/ml, caspofungin 5 µg/ml, fluconazole 80 µg/ml or amphotericin B 8 µg/ml. Control and antifungal-exposed biofilms were recovered at t= 0, 30, 60 and 120 min post exposure to antifungal.
ORGANISM(S): Candida albicans 
2010-03-02 | E-MEXP-2436 | biostudies-arrayexpress
MetabolomicsPeroxin Pex8 couples stress responses, antifungal tolerance and virulence regulation in Candida albicans

Candida albicans, a World Health Organization critical-priority fungal pathogen, represents the predominant cause of candidemia. Therapeutic failure is sometimes driven by antifungal tolerance, a phenotype distinct from resistance, whose underlying mechanisms remain incompletely defined....

2026-03-12 | MTBLS13170 | MetaboLights
TranscriptomicsTranscriptome analysis of Cryptococcus neoformans strain H99 in response to exposure to amphotericin B
Log phase of Cryptococcus neoformans strain H99 was exposed to amphotericin B (1.5μg/ml) or vehicle (control) for 3h. Transcriptome of drug treated cells were compared to no treatment cells.
ORGANISM(S): Cryptococcus neoformans var. grubii H99 
2023-08-16 | E-MTAB-12683 | biostudies-arrayexpress
TranscriptomicsWhole genome sequencing of Candida albicans derived adaptors to flucytosine, aureobasidin A and amphotericin B
We exposed Candida albicans reference strain SC5314 to different drugs (flucytosine, aureobasidin A, amphotericin B), and sequenced some of the adaptors.
ORGANISM(S): Candida albicans 
2021-05-07 | E-MTAB-10394 | biostudies-arrayexpress
TranscriptomicsRNA-seq of some amphotericin B adaptors in Cryptococcus neoformans
Cryptococcus neoformans strain H99 was exposed to 3μg/ml amphotericin B. Among the amphotericin B-tolerant adaptors, transcriptomes of four adaptors (TJ1844, TJ1849, TJ1852, TH1854) were analyzed and compared to wild type strain H99.
ORGANISM(S): Cryptococcus neoformans var. grubii H99 
2023-08-10 | E-MTAB-12679 | biostudies-arrayexpress
TranscriptomicsTJ1843 derived amphotericin B (8ug/ml) adaptors
In this project, H99 is the wild type Cryptococcus neoformans strain. TJ1843 is a strain with segmental disomy of chromosome 11. TJ1843 is a derivative of H99. Approximately 1 million cells of TJ1843 were spread on YPD plate supplemented with 8 ug/ml amphotericin B. Randomly 27 adaptors (TJ3409-TJ34...
ORGANISM(S): Cryptococcus neoformans var. grubii H99 
2023-05-13 | E-MTAB-12566 | biostudies-arrayexpress
GenomicsDNA-seq of Cryptococcus neoformans H99 derived amphotericin B adaptors
Approximately 1 million cells of Cryptococcus neoformans lab strain H99 were spread on YPD plate supplmemented with 3ug/ml amphotericin B. Randomly 30 adaptors (TJ1832 - TJ1861) were chosen. The parent and all the 30 adaptors were sequenced.
ORGANISM(S): Cryptococcus neoformans var. grubii H99 
2023-05-11 | E-MTAB-12493 | biostudies-arrayexpress
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