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MetabolomicsAMPK activation orchestrated replicative senescence of periodontal ligament stem cells via regulating metabolomics

BACKGROUND: Periodontal ligament mesenchymal stem cells (PDLSCs) are a promising cell resource for cell-based regenerative medicine in dentistry. PDLSCs inevitably acquire a senescent phenotype after prolonged in vitro expansion, and the key regulators of cells during replicative...

2022-11-15 | MTBLS4568 | MetaboLights
TranscriptomicsActivated AMPK and prostaglandins are involved in the response to conjugated linoleic acid and are sufficient to cause lipid reductions in adipocytes
Activated AMPK and prostaglandins are involved in the response to conjugated linoleic acid and are sufficient to cause lipid reductions in adipocytes. Trans-10, cis-12 conjugated linoleic acid (t10c12 CLA) reduces triglyceride levels in adipocytes. AMP-activated protein kinase (AMPK) was recently de...
ORGANISM(S): Mus musculus 
2010-08-10 | E-GEOD-17404 | biostudies-arrayexpress
GenomicsAMPK activator-treated human cardiac spheres have enhanced maturation and enable pathological modeling
AMPK activator-treated human cardiac spheres have enhanced maturation and enable pathological modeling
PRJNA840926 | ENA
ProteomicsAMPK-dependent activation of the Cyclin Y/CDK16 complex controls autophagy
The AMP-activated protein kinase (AMPK) is a master sensor of the cellular energy status and is crucial for the adaptive response to limited energy availability. AMPK is implicated in the regulation of many cellular processes, including autophagy. However, the precise mechanisms by which AMPK contro...
ORGANISM(S): Homo sapiens (Human) 
2020-02-17 | PXD009968 | Pride
Human Autophagy Nanolc-msms Phosphorylation 
ProteomicsAMPK activator 991 specifically activates SnRK1 and thereby affects seed germination in rice
Sucrose non-fermenting-1-related protein kinase 1 (SnRK1) is a central regulator of metabolism and developmental transition in plant. Compound 991 is a well-known 5′-adenosine monophosphate activated protein kinase (AMPK) activator in mammals. SnRK1 and AMPK are highly conserved. However, whether 99...
ORGANISM(S): Oryza sativa (Rice) 
2024-02-04 | PXD044360 | Pride
Rice Snrk1 Ampk activator Germination Phosphoproteomics 
TranscriptomicsMicroarray skeletal muscle miR-499 overexpressing mice
This experiment was conducted to identify target genes of the microRNA-499 in skeletal muscle of transgenic mice that overexpressed miR-499. The following abstract from the submitted manuscript describes the major findings of this work. Coupling of mitochondrial function and skeletal muscle f...
ORGANISM(S): Mus musculus 
2016-09-03 | E-GEOD-72581 | biostudies-arrayexpress
TranscriptomicsAMPK activation exerts anti-senescence effect in human follicle dermal papilla cells
We investigated the role of AMPK activation in the progression of senescence in HFDPCs. The anti-senescence effects of adenine, a recently identified AMPK activator, were determined in a comparison with AICAR, a pharmacological AMPK activator, in HFDPCs. The results showed that either adenine or AIC...
ORGANISM(S): Homo sapiens 
2014-11-01 | E-GEOD-62798 | biostudies-arrayexpress
GenomicsAMPK activator O304 protects against kidney aging through promoting energy metabolism and autophagy
AMPK activator O304 protects against kidney aging through promoting energy metabolism and autophagy
PRJNA791683 | ENA
TranscriptomicsConjugated linoleic acid activates AMPK and reduces adiposity more effectively when used with metformin
Trans-10, cis-12 conjugated linoleic acid (t10c12 CLA) causes dramatic reductions in white adipose tissue in mice but has had limited effectiveness in humans. Determination of the signaling pathways involved may lead to better regulation of adiposity. T10c12 CLA was found to activate AMP-activating...
ORGANISM(S): Mus musculus 
2009-11-01 | E-GEOD-14888 | biostudies-arrayexpress
TranscriptomicsAMPK activator-treated human cardiac spheres have enhanced maturation and enable pathological modeling
To investigate the functions of AMPK activation on maturation of hiPSC derived cardiomyocytes, we treated 3D hiPSC derived cardiomyocytes with AMPK activator EX229 at 10 µM for 7 days. Transcriptomic analyse was performed to identify molecular actions of AMPK activation.
ORGANISM(S): Homo sapiens 
2022-05-27 | GSE203480 | GEO
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