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TranscriptomicsSingle-cell RNA sequencing (scRNA-seq) profiles of fetal human cortical neurons
The dataset consists of single-cell RNA sequencing (scRNA-seq) profiles of fetal human cortical neurons (10 weeks gestation) under six experimental conditions: Sample 1 – Control: Untreated cells. Sample 2 – PFF treated: Cells exposed to alpha-synuclein pre-formed fibrils (PFF) for 14 days. Sample 3...
ORGANISM(S): Homo sapiens 
2026-04-09 | E-MTAB-16863 | biostudies-arrayexpress
ProteomicsPhenotypic manifestation of-synuclein strains amplified from Parkinson’s disease and multiple system atrophy in human dopaminergic neurons
Although-synuclein is implicated in the pathogenesis of Parkinson’s disease and related disorders, it remains unclear whether specific conformations or levels of-synuclein assemblies are toxic and how they cause progressive loss of human dopaminergic neurons. To address this issue, we used iPSC-deri...
ORGANISM(S): Homo sapiens (Human) 
2021-04-19 | PXD024198 | Pride
Silac -synuclein Bioid Parkinson’s disease 
ProteomicsStructure-function relationship of alpha-synuclein fibrillar polymorphs derived from distinct synucleinopathies (Part 1)
The aggregation of the protein alpha-synuclein (αSyn) is a common feature of multiple neurodegenerative diseases collectively called synucleinopathies, for which the pathobiology is not well understood. The different phenotypic characteristics of the synucleinopathies Parkinson’s disease (PD), Demen...
ORGANISM(S): Homo sapiens (Human) 
2026-06-08 | PXD058124 | Pride
Synucleopathies Structural proteomics  mass spectrometry  chemical surface modification  nhs-biotin  nanolc-msms Amplified synuclein fibrils 
UnknownQuaternary structure of patient-homogenate amplified α-synuclein fibrils modulates seeding of endogenous α-synuclein.
Not available
S-EPMC9525671 | biostudies-literature
UnknownStructural heterogeneity of α-synuclein fibrils amplified from patient brain extracts.
Not available
S-EPMC6893031 | biostudies-literature
UnknownUse of Amplified Lewy Body Dementia Fibrils and Autoradiography to Characterize Binding of Radioligand Tg-1-90B to Alpha-Synuclein Fibrils in Postmortem Brain Tissue.
Not available
S-EPMC12468313 | biostudies-literature
UnknownMouse α-synuclein fibrils are structurally and functionally distinct from human fibrils associated with Lewy body diseases.
Not available
S-EPMC11800946 | biostudies-literature
ProteomicsDoes alpha synuclein strain or GCase enzyme activity drive clinical aggression in GBA-PD?
Parkinson’s disease (PD) is a neurodegenerative disease characterized by progressive motor symptoms and alpha-synuclein (αsyn) aggregation in the nervous system. For unclear reasons, PD patients with certain GBA mutations (GBA-PD) have a more aggressive clinical progression. Two testable hypotheses ...
ORGANISM(S): Mus musculus (Mouse) 
2024-02-22 | PXD045437 | Pride
Parkinson's disease Biotinylation by antibody recognition Preformed fibrils Gba1 
TranscriptomicsPhenotypic manifestation of alpha-synuclein strains derived from Parkinson’s disease and multiple system atrophy in human dopaminergic neurons
Althougha-synuclein is implicated in the pathogenesis of Parkinson’s disease and related disorders, it remains unclear whether specific conformations or levels ofa-synuclein assemblies are toxic and how they cause progressive loss of human dopaminergic neurons. To address this issue, we used iPSC-...
ORGANISM(S): Homo sapiens 
2021-04-13 | GSE171999 | GEO
UnknownThermodynamic stability modulates chaperone-mediated disaggregation of α-synuclein fibrils.
Not available
S-EPMC12622358 | biostudies-literature
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