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Whole genome expression in Parkinson disease and neurologically healthy control prefrontal cortex Brodmann area 9 samples
ORGANISM(S): Homo sapiens 
We used 500 melanized dopamine neurons isolated from post-mortem human substantia nigra pars compacta of each sample with laser capture microdissection. Total RNA was extracted with Arcturus PicoPure RNA extraction kit and amplified two times with Arcturus RiboAmp RNA amplification kit. the samples ...
ORGANISM(S): Homo sapiens 
Dysfunctional Parkin-mediated mitophagic culling of senescent or damaged mitochondria is a major pathological process underlying Parkinson disease and a potential genetic mechanism of cardiomyopathy. Despite epidemiological associations between Parkinson disease and heart failure, the role of Parkin...
ORGANISM(S): Mus musculus 
We used microarrays to detail the global program of gene expression underlying Parkinson's disease Experiment Overall Design: Substantia nigra tissue from postmortem brain of normal and Parkinson disease patients were used for RNA extraction and hybridization on Affymetrix microarrays: 9 replicates ...
ORGANISM(S): Homo sapiens 
Microarrays of frontal cortex (area 8) of Parkinson cases and controls
ORGANISM(S): Homo sapiens 

We have an ongoing study that has recruited families having at least a sibling pair with Parkinson disease (PD). Families have been screened for mutations in known PD causative genes (LRRK2, parkin, etc). Following review of families without a causative mutation, we selected families for ...

This SuperSeries is composed of the following subset Series: GSE29772: CNV analysis for Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations GSE29773: Gene Expression Data for Generation of isogenic pluripotent stem cells differing exclusiv...
ORGANISM(S): Homo sapiens 
Peripheral blood samples were collected from (Heavy metal exposer- Parkinson disease)HME-PD, (Heavy metal non-exposer- Parkinson disease) NHME-PD, and healthy controls. Total RNA was isolated and profiled using the Affymetrix GeneChip™ miRNA 3.1 Array. Arrays were hybridized, washed, stained, scanne...
ORGANISM(S): Homo sapiens 
Parkinson Disease Frontal Cortex Transcriptomic analysis
We have used HiRIEF (High Resolution Isoelectric Focusing) LC-MS proteomics with isobaric tags (TMT10plex) to compare 32 post-mortem human brains in the prefrontal cortex (Brodmann area 9) of prospectively followed patients with Alzheimer`s disease (AD), Parkinson`s disease with dementia (PDD), deme...
ORGANISM(S): Homo sapiens (Human) 
2017-12-08 | PXD006122 | Pride
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