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MetabolomicsSPE-IMS-MS: An automated platform for sub-sixty second surveillance of endogenous metabolites and xenobiotics in biofluids
Characterization of endogenous metabolites and xenobiotics is essential to deconvoluting the genetic and environmental causes of disease. However, surveillance of chemical exposure and disease-related changes in large cohorts requires an analytical platform that offers rapid measurement, high sensit...
2017-02-14 | MTBLS427 | MetaboLights
MetabolomicsNovel Minor Groove Binders cure animal African trypanosomiasis in an in vivo mouse model
Animal African trypanosomiasis (AAT) is a significant socioeconomic burden for sub-Saharan Africa because of its huge impact on livestock health. Existing therapies including those based on minor groove binders (MGBs), such as the diamidines, which have been used for decades, have now lost efficacy ...
2022-01-18 | MTBLS882 | MetaboLights
TranscriptomicsSustained expression of cyclin D1 or cyclin D1/KE in mouse mammary gland
Analysis of mammary glands from tet-inducible(rtTA) transgenic mice expressing cyclin D1 using Affymetrix Mouse Gene 1.0 ST GeneChip arrays. MMTV-rtTA transgenic mice (MMTV-Mouse Mammary Tumor Virus promoter) were cross-mated to cyclin D1 transgenic mice under control of tet operon. 8-week-old tetr...
ORGANISM(S): Mus musculus 
2013-12-31 | E-GEOD-43216 | biostudies-arrayexpress
ProteomicsCell-type specific labelling of glycoproteins in engineered K-562 cells (BOCTAG)
We report a strategy termed Bio-Orthogonal Cell line-specific Tagging of Glycoproteins (BOCTAG). Cells are equipped by transfection with an artificial biosynthetic pathway (mut-AGX1/NahK) that transforms an alkyne tagged sugar into the corresponding nucleotide-sugar. Only transfected cells incorpora...
ORGANISM(S): Homo sapiens (Human) 
2022-09-10 | PXD035430 | Pride
Human Mono-culture Silac Whole lysates K-562 
ProteomicsCell-type specific labelling of O-linked glycoproteins in engineered K-562 cells
We report a strategy termed Bio-Orthogonal Cell line-specific Tagging of Glycoproteins (BOCTAG). Cells are equipped by transfection with an artificial biosynthetic pathway (mut-AGX1/NahK) that transforms an alkyne tagged sugar into the corresponding nucleotide-sugar. Only transfected cells incorpora...
ORGANISM(S): Homo sapiens (Human) 
2022-09-10 | PXD035437 | Pride
Human Mono-culture Silac Whole lysates K-562 
MetabolomicsFecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial

Fecal microbiota transplantation (FMT) represents a potential strategy to overcome resistance to immune checkpoint inhibitors in patients with refractory melanoma; however, the role of FMT in first-line treatment settings has not been evaluated. We conducted a multicenter phase I trial combining ...

2025-02-27 | MTBLS711 | MetaboLights
UnknownCardiomyocyte-specific disruption of Cathepsin K protects against doxorubicin-induced cardiotoxicity.
Not available
S-EPMC5992138 | biostudies-literature
UnknownQuantification of vitamin K (phylloquinone and menaquinones 4-10) in various shellfish.
Not available
S-EPMC12011545 | biostudies-literature
UnknownPathological manifestation of human endogenous retrovirus K in frontotemporal dementia.
Not available
S-EPMC8788987 | biostudies-literature
UnknownCytochrome P450 Family 4F2 and 4F11 Haplotype Mapping and Association with Hepatic Gene Expression and Vitamin K Hydroxylation Activity.
Not available
S-EPMC10928895 | biostudies-literature
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