Sort   by:  
 Page size 
MetabolomicsPeripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models
Reversible and sub-lethal stresses to the mitochondria elicit a program of compensatory responses that ultimately improve mitochondrial function, a conserved anti-aging mechanism termed mitohormesis. Here, we show that harmol, a member of the beta-carbolines family with anti-depressant properties, i...
2023-05-26 | MTBLS7533 | MetaboLights
UnknownDevelopment of a Novel Class of Pyridazinone Derivatives as Selective MAO-B Inhibitors.
Not available
S-EPMC9230784 | biostudies-literature
ProteomicsCatechol-modified protein extracts from human heart mitochondria after APBA chromatography
Catecholamine metabolism via monoamine oxidase (MAO) contributes to cardiac injury in models of ischemia and diabetes, but the pathogenic mechanisms involved are unclear. MAO deaminates norepinephrine (NE) and dopamine (DA) to produce H2O2 and highly reactive ‘catecholaldehydes,’ which may be toxic ...
ORGANISM(S): Homo sapiens (Human) 
2020-10-21 | PXD021759 | Pride
Mitochondrial proteomics Atrial mitocardium Mao Type 2 diabetes Catecholamine metabolism Atrial tissue Human Cardiomyopathy 
UnknownNew Insights on the Activity and Selectivity of MAO-B Inhibitors through In Silico Methods.
Not available
S-EPMC10253494 | biostudies-literature
UnknownCoumarin-Chalcone Hybrids as Inhibitors of MAO-B: Biological Activity and In Silico Studies.
Not available
S-EPMC8122463 | biostudies-literature
UnknownRethinking, reducing, and refining the classical oral tyramine challenge test of monoamine oxidase (MAO) inhibitors.
Not available
S-EPMC10582662 | biostudies-literature
UnknownBinding mechanism of naringenin with monoamine oxidase - B enzyme: QM/MM and molecular dynamics perspective.
Not available
S-EPMC8055563 | biostudies-literature
MetabolomicsEcological adaptation and succession of human fecal microbial communities in an automated in vitro fermentation system
Longitudinal studies of gut microbiota following specific interventions are vital for understanding how they influence host health. However, robust longitudinal sampling of gut microbial communities is a major challenge, which can be addressed using in vitro fermenters hosting complex microbial comm...
2021-07-15 | MTBLS2531 | MetaboLights
MetabolomicsSMN deficiency perturbs monoamine neurotransmitter metabolism in spinal muscular atrophy

Beyond motor neuron degeneration, homozygous mutations in the survival motor neuron 1 (SMN1) gene cause multiorgan and metabolic defects in patients with spinal muscular atrophy (SMA). However, the precise biochemical features of these alterations and the age of onset in the brain and peripheral ...

2023-11-27 | MTBLS8784 | MetaboLights
UnknownAre Terminal Alkynes Necessary for MAO-A/MAO-B Inhibition? A New Scaffold Is Revealed.
Not available
S-EPMC11174103 | biostudies-literature
Sort   by:  
 Page size