Cardiomyopathy - OmicsDI

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Unknown (11220)
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Organisms

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synthetic construct (2)
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Organisms

Mus musculus (430)
Homo sapiens (338)
Rattus norvegicus (35)
Danio rerio (11)
Canis lupus familiaris (9)
Sus scrofa (7)
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unidentified (2)
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human gut metagenome (2)
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Trypanosoma cruzi (1)
Mus (1)
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Mus musculus domesticus (1)
Mammalia (1)
Severe acute respiratory syndrome coronavirus 2 (1)
mouse gut metagenome (1)

Repository

ENA (1092)
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PMR (1)

Tissue

Heart (124)
Cell culture (19)
Cardiac muscle cell (17)
Plasma Non-glyco (10)
Blood plasma (9)
Heart (5)
Blood cell (4)
Cardiac muscle myoblast (3)
Cardiomyocyte cell line (3)
Stem cell (3)
Fibroblast (3)
Permanent cell line cell (3)
Fetal cardiomyocyte (2)
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Cardiocyte (2)
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Adult (1)
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Disease

Cardiovascular system disease (28)
Cardiomyopathy (11)
Dilated cardiomyopathy (8)
Normal (6)
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Arrhythmogenic right ventricular cardiomyopathy (4)
Heart failure (4)
Type 2 diabetes mellitus (4)
Cardiomyopathy (3)
Heart disease (2)
Barth syndrome (2)
Myocardial ischemia (2)
Ischemic cardiomyopathy (1)
Normal transgenic (transgenic betaARKct) (1)
Congestive heart failure (1)
Arrhythmias and right ventricular dysfunction (1)
TAC operated 1 hour after surgery (1)
Idiopathic dilated cardiomyopathy (1)
Cataract (1)
Diabetes Mellitus (1)
Carcinoma (1)
Not Available (1)
Diabetes (1)
Peripartum cardiomyopathy (1)
Cardiovascular system (1)
Hypertrophic cardiomyopathy (1)
Polyneuropathy (1)
Diabetic angiopathy (1)
Amyloidosis (1)
Restrictive cardiomyopathy (1)

Technology Type

Mass Spectrometry (194)
Shotgun proteomics (91)
Bottom-up proteomics (43)
Data-dependent acquisition (19)
Data-independent acquisition (18)
Affinity purification coupled with mass spectrometry proteomics (16)
Mass spectrometry assay (11)
Mass spectrometry (9)
SWATH MS (9)
Gel-based experiment (8)
Top-down proteomics (6)
ESI (4)
Illumina (2)
MSE (2)
All-ion fragmentation (2)
DiaPASEF (2)
HDMSE (2)
SRM/MRM (2)
HiSeq X Ten (ILLUMINA) (1)
ILLUMINA, Illumina HiSeq 2500, Illumina HiSeq 2500 (ILLUMINA) (1)
Illumina HiSeq 2500 (ILLUMINA) (1)
ILLUMINA, Illumina MiSeq (1)
Illumina HiSeq 2000, ILLUMINA (1)
NMR spectroscopy (1)
API (1)
SomaScan affinity proteomics (1)
Mass spectrometry imaging (1)
Chemical cross-linking coupled with mass spectrometry proteomics (1)

Instrument Platform

NextSeq 500 (7)
Illumina HiSeq 4000 (6)
NextSeq 2000 (5)
Illumina HiSeq 2500 (5)
Illumina NovaSeq 6000 (5)
Illumina HiSeq 2000 (5)
NextSeq 550 (4)
Illumina MiSeq (4)
- (3)
Illumina Genome Analyzer II (2)
Illumina HiSeq 1000 (2)
Illumina HiSeq 3000 (2)
Illumina Genome Analyzer IIx (2)
7200 7890A Q-TOF GC/MS (Agilent Instrument Model) (2)
API 5500 QTRAP (AB Sciex) (2)
Nanodrop 2000c spectrophotometer (1)
Lab Chip GX touch HT (Perkin Elmer) (1)
Wollenberger tongs (1)
Zephyr G3 NGS workstation (1)
MiRNeasy Micro kit (1)
Radial JawTM (1)
Do not apply (1)
Agilent Bioanalyzer (1)
Not applicable (1)
Illumina Genome Analyzer (1)
Illumina NovaSeq X (1)
Ion Torrent Proton (1)
DNBSEQ-G400 (1)
MinION (1)
BGISEQ-500 (1)

Publication Date

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2023 (126)
2021 (81)
2020 (62)
2015 (60)
2014 (59)
2019 (51)
2016 (46)
2013 (46)
2010 (44)
2017 (42)
2012 (36)
2011 (32)
2018 (27)
2007 (20)
2009 (19)
2008 (19)
2006 (12)
2004 (6)
2005 (4)
2003 (3)

UNIPROT ID/AC

O43280 (10)
M0QZL2 (10)
Q9BWV1 (10)
O95390 (10)
Q86YD3 (10)
Q7LFX5 (10)
Q6UXH9 (10)
A8TX70 (10)
Q86Z14 (10)
Q9Y274 (10)
Q9NS98 (10)
Q9HCL0 (10)
Q99983 (10)
Q93070 (10)
Q8TER0 (10)
Q02763 (10)
Q02747 (10)
P41159 (10)
P08887 (10)
P04054 (10)
Q96KG7 (10)
P47972 (10)
Q13275-2 (10)
Q9NTU7 (10)
P23467-3 (10)
Q13275 (10)
Q16663 (10)
Q99972 (10)
O95633 (10)
Q8IZP9 (10)

ENSEMBL ID

ENSG00000229353 (10)
ENSG00000170477 (10)

CHEBI ID

CHEBI:15891 (5)
CHEBI:16704 (5)
CHEBI:16335 (5)
CHEBI:16750 (5)
CHEBI:17562 (5)
CHEBI:15611 (4)
CHEBI:18012 (4)
CHEBI:30769 (4)
CHEBI:15354 (4)
CHEBI:15846 (4)
CHEBI:15428 (4)
CHEBI:16737 (4)
CHEBI:16919 (4)
CHEBI:16708 (4)
CHEBI:17895 (3)
CHEBI:17115 (3)
CHEBI:16643 (3)
CHEBI:18050 (3)
CHEBI:17295 (3)
CHEBI:15603 (3)
CHEBI:17196 (3)
CHEBI:16467 (3)
CHEBI:17053 (3)
CHEBI:16414 (3)
CHEBI:18019 (3)
CHEBI:16015 (3)
CHEBI:60175 (3)
CHEBI:30887 (3)
CHEBI:18132 (3)
CHEBI:7916 (3)

Metabolite Name

Leucine (6)
Sarcosine (6)
Adenosine (6)
Adenine (6)
Creatinine (6)
Glycine (5)
Creatine (5)
Taurine (5)
Choline (5)
Uridine (5)
4-Hydroxybenzoic acid (4)
L-Tyrosine (4)
Linoleic acid (4)
Azelaic acid (4)
Uracil (4)
Hypoxanthine (4)
Pyroglutamic acid (4)
Threonic acid (3)
Oxalic acid (3)
Heptadecanoic acid (3)
Diacetyl (3)
Phenol (3)
Cholesterol sulfate (3)
Acetylglycine (3)
Pentadecanoic acid (3)
Glycolic acid (3)
Histidine (3)
Betaine (3)
Phosphate (3)
Triptophenolide (3)

First Public Date

2025 (171)
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2014 (103)
2021 (82)
2020 (56)
2019 (47)
2017 (39)
2018 (24)
2016 (19)
2015 (18)
2013 (13)
2012 (1)

Study status

Recruiting (2)
Completed (1)

Lab affiliation

Ludwig-Maximilians-Universität München Genzentrum Laboratory for Functional Genome Analysis Feodor-Lynen-Str. 25 D-81377 München (4)
The University of Melbourne (4)
Institute of Clinical Chemistry, University Medical Center Goettingen (3)
University Medical Center Goettingen, Department of Clinical Chemistry, Core Facility Proteomics (3)
Department of Thoracic Surgery, First Affiliated Hospital of Kunming Medical University, Kunming 650000, Yunnan, China. (2)
University of Konstanz, Department of Biology, Biophysics & Structural Biology, Germany (2)
Affiliation of Qiutao Xu: State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, College of Agriculture, Guangxi University, Nanning 530004, China (2)
Experimental Pharmacology Mannheim (EPM), European Center for Angioscience, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany (2)
Department of Radiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China. (2)
Harbin Medical University (2)
Institute for Genetics and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany (2)
Institut Pasteur 25 Rue du Docteur Roux Paris 75015 (2)
King’s British Heart Foundation Centre of Research Excellence, King's College London, United Kingdom (2)
EDyP (2)
Amsterdam UMC, Vrije Universiteit Amsterdam, Medical Oncology, Cancer Center Amsterdam, OncoProteomics Laboratory, Amsterdam, Netherlands (2)
Genome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany; Genome Center, Department of Genetics, Stanford University School of Medicine, CA, USA. (1)
2The Rappaport Institute and the Bruce Rappaport Faculty of Medicine, Technion – Israel Institute of Technology, Israel. (1)
Cardiac Proteomics & Systems Biology Group, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen (1)
Prof. Dr. Albert Sickmann President Leibniz-Institut für Analytische Wissenschaften – ISAS – e.V. Otto-Hahn-Straße 6b 44227 Dortmund, Germany P: +49 (0)2 31.13 92-100 F: +49 (0)2 31.13 92-200 albert.sickmann@isas.de www.isas.de twitter.com/isas_Leibniz (1)
Mitochondrial biology group, Institut Pasteur, Paris (1)
Klinik und Poliklinik Innere Medizin I, Klinikum rechts der Isar - Technical University of Munich, Munich, Germany (1)
Department of Medicine, University of California San Diego, La Jolla, California 92093 (1)
Department of Physiology, University of Toronto Ted Rogers Centre for Heart Research Toronto, Ontario, Canada (1)
Max Planck Institut for Molecular Biomedicine Bioanalytical Mass Spectromentry Röntgenstr. 20 48149 Münster, Germany (1)
Charles Perkins Centre, School of Life and Environmental Sciences, University of Sydney, Camperdown, NSW, Australia. (1)
Professor of Medicine Tufts University School of Medicine Principal Investigator Molecular Cardiology Research Institute Tufts Medical Center Boston, MA, USA (1)
Max-Planck-Institute for Biology of Ageing Department of Mitochondrial Proteostasis Joseph-Stelzmann-Str. 9b 50931 Cologne Email: tlanger@age.mpg.de (1)
University Medical Center Goettingen, Department of Clinical Chemistry, Core Facility Proteomics, Goettingen/Germany (1)
Department of Cardiac Development and Remodelling, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany. (1)
Head of the Mass Spectrometry platform of the Institut Curie (LSMP) (1)

Keyword

Neglected Diseases (1)
Orphan Diseases (1)
Rare Disease Research (1)
Registries (1)
Batten Disease (1)
Mucolipidosis IV (1)
Undiagnosed (1)
Uncommon Disease (1)
Hypersomnia (1)
Marinesco-Sjogren Syndrome (1)
4p-/Wolf-Hirschhorn Syndrome (1)
Wiedermann-Steiner Syndrome (1)
Hemophagocytic Lymphohistiocytosis (HLH) (1)
Behcet’s Disease (1)
Jansen metaphyseal chondrodysplasia (1)
Chronic recurrent multifocal osteomyelitis (CRMO) (1)
Hereditary Sensory and Autonomic Neuropathy (1)
Nephropathic infantile cystinosis (1)
Ocular cystinosis (1)
Spinal Bulbar Muscular Atrophy (SBMA) (1)
Mucolipidosis (1)
Mitochondrial aminoacyl-tRNA synthetases (Mt-aaRS Disorders) (1)
Shine Syndrome (1)
Intestinal Bromhidrosis Syndrome (1)
Autosomal recessive extra oral halitosis (1)
CACNA1H mutation (1)
Dimethylglycine dehydrogenase deficiency (1)

Classification

protozoa (1)
viruses (1)

Modification

15.994915 (1)
57.021464 (1)
Not available (1)

Study type

Transcription profiling by array (161)
RNA-seq of coding RNA (72)
ChIP-seq (8)
Methylation profiling by array (8)
Methylation profiling by high throughput sequencing (7)
Other (6)
RNA-seq of non coding RNA (6)
ChIP-chip by tiling array (5)
RNA-seq of total RNA (4)
Human - High-throughput sequencing (3)
Animal - High-throughput sequencing (3)
Unknown experiment type (2)
Transcription profiling by tiling array (2)
MicroRNA profiling by high throughput sequencing (2)
DNA-seq (2)
RNA-seq of coding RNA from single cells (2)
Observational (2)
CLIP-Seq (1)
Cell line - High-throughput sequencing (1)
Genotyping by array (1)
Genotyping by high throughput sequencing (1)
Observational patient registry (1)

Release Date

2022 (1439)
2025 (1370)
2023 (1334)
2021 (1234)
2024 (1101)
2020 (867)
2019 (615)
2018 (579)
2017 (501)
2016 (451)
2015 (384)
2014 (339)
2013 (240)
2026 (186)
2012 (185)
2010 (176)
2011 (169)
2009 (90)
2008 (78)
2007 (60)
2006 (38)
2005 (20)
2000 (12)
2002 (11)
2004 (10)
2003 (9)
2001 (9)
1999 (4)
1997 (2)
1998 (1)

Location

United States (2)
Australia (1)
Belgium (1)

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Cardiac disruption of SDHAF4-mediated mitochondrial complex II assembly promotes dilated cardiomyopathy

Succinate dehydrogenase, which is known as mitochondrial complex II, has proven to be a fascinating machinery, attracting renewed and increased interest in its involvement in human diseases. Herein, we find that succinate dehydrogenase assembly factor 4 (SDHAF4) is downregulated in cardiac muscle in...

2022-08-12 | MTBLS4579 | MetaboLights

Untargeted Metabolomic Profiling of Left Ventricular Myocardium in a Mouse Model of Diabetic Cardiomyopathy

This study characterizes metabolic alterations in the left ventricular myocardium of a high-fat diet and streptozotocin-induced mouse model of diabetic cardiomyopathy. Untargeted LC–MS/MS metabolomics was performed using a Vanquish UHPLC system coupled to an Orbitrap Exploris 120 mass spectrometer. ...

2026-07-20 | MTBLS15043 | MetaboLights

Gut Microbiota-Derived Indole-3-Propionic Acid Ameliorates Diabetic Cardiomyopathy by Regulating Mitochondrial Dynamics via the AhR/Nrf2 Pathway

This study investigated serum metabolic alterations in a mouse model of diabetic cardiomyopathy and evaluated the protective role of the gut microbiota-derived metabolite indole-3-propionic acid. Serum samples from mice were analyzed using untargeted LC-MS metabolomics. The study focused on the rela...

2026-07-26 | MTBLS14953 | MetaboLights

Untargeted lipidomics of hypertrophic cardiomyopathy (part II)

Not available

ORGANISM(S): Homo sapiens

ST001887 | MetabolomicsWorkbench

Untargeted metabolomics of hypertrophic cardiomyopathy (part I)

Not available

ORGANISM(S): Homo sapiens

ST001886 | MetabolomicsWorkbench

Transcriptome profiling of peripheral blood from patients with hypertrophic cardiomyopathy (HCM) compared to healthy controls

This study investigates the molecular mechanisms of hypertrophic cardiomyopathy (HCM), a common genetic heart disease where the link between cardiac remodeling and immune response is not fully understood. We aimed to identify novel diagnostic biomarkers and explore transcriptomic alterations in peri...

ORGANISM(S): Homo sapiens

2025-11-17 | E-MTAB-15843 | biostudies-arrayexpress

Molecular remodeling of ion channels, exchangers and pumps in atrial and ventricular myocytes in ischemic cardiomyopathy: left ventricle DCM

We wanted to see whether the set of affected genes in ischemic cardiomyopathy (ICM) is the same or different as compared to dilated cardiomyopathy (DCM). To find this out, we placed the single DCM sample on the same microarray slide with the ICM samples. Analysis of microarray data with ICM samples ...

ORGANISM(S): Homo sapiens

2010-06-17 | E-GEOD-17530 | biostudies-arrayexpress

Human Cardiac Proteome of Hypertrophic Cardiomyopathy

This study utilized TMT to characterize the cardiac proteomic differences between patients with hypertrophic cardiomyopathy and controls.

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

2023-04-28 | MSV000091821 | MassIVE

Human hypertrophic cardiomyopathy cardiac tissue phosphoproteomics

This study used TMT-pro method to look for phosphoproteomic differences in heart tissue of patients with hypertrophic cardiomyopathy and controls

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

2023-04-28 | MSV000091822 | MassIVE

Transcription profiling of human hearts exhibiting ischemic and nonischemic cardiomyopathy

Pre-LVAD and explanted ischemic and nonischemic cardiomyopathy and nonfailing hearts all normalized with RMA