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Salmonella Typhimurium establishes systemic infection by replicating in host macrophages. Here we show that macrophages infected with S. Typhimurium exhibit upregulated glycolysis and decreased serine synthesis, leading to accumulation of glycolytic intermediates. The effects on...

2024-05-22 | MTBLS2347 | MetaboLights
This assay aims to identify the composition of an unidentified protein band (~10 kDa) in Edwardsiella piscicida’s extracellular proteins (ECPs). To make this end, this protein band was cut, followed by gel band excision and LC-MS/MS identification.
ORGANISM(S): Edwardsiella tarda EIB202 
2024-01-15 | PXD048313 | Pride
This study systematically investigated the impact of ACE2 knockout (ACE2KO) on hepatic metabolic homeostasis and its molecular mechanisms, using integrated transcriptomic, proteomic, and metabolomic profiling. ACE2 deficiency exacerbates hepatic lipid accumulation, as evidenced by elevated total cho...
2025-06-23 | MTBLS12389 | MetaboLights
Plants due to their sessile nature rely on root systems to mediate many challenging stimuli. A major cornerstone of the responses are root proteomes, shaped to overcome biotic and abiotic cues. Proteome-wide reprogramming events are magnified in root meristems due to their active protein production....
ORGANISM(S): Hordeum vulgare (Barley) 
2021-04-14 | PXD021731 | Pride
Lipid droplets (LDs), as innate immune hubs, function in the front line of antimicrobial defense involved in the ongoing host-pathogen arms race. Particularly for intracellular bacterial pathogens, the endowed capacity to resist host LDs can effectively facilitate pathogen in vivo colonization and e...
2025-07-04 | MTBLS9590 | MetaboLights
Eco1 is an acetyltransferase subunit of the cohesin complex and acts during DNA replication to establish cohesion between sister chromatids. However, cohesin has additional functions in gene expression, DNA damage repair, and higher-order organization of chromosomes. The eco1 mutant W216G disrupts a...
ORGANISM(S): Saccharomyces cerevisiae 
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