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TranscriptomicsRNA-seq of Breast Implant-Associated Anaplastic Large Cell Lymphoma
Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is an anaplastic lymphoma kinase-negative (ALKneg) T-cell lymphoma. Here, we provide RNA-seq data of four BIA-ALCL and four ALCL cell lines:TLBR-1, TLBR-2, TLBR-3, TLBR-4 and DEL (two replicates), KARPAS-299, KI-JK, SUP-M2 (two repl...
ORGANISM(S): Homo sapiens 
2025-01-14 | E-MTAB-14735 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human anaplastic large cell lymphoma cell lines - kinase signature
Anaplastic Large Cell Lymphomas (ALCL) represent a subset of lymphomas in which the Anaplastic Lymphoma Kinase (ALK) gene is frequently fused to the NPM gene. We previously demonstrated that the constitutive phosphorylation of ALK chimeric proteins is sufficient to induce cellular transformation in ...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6184 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of 32 human Anaplastic Large Cell Lymphomas (ALCL) and 5 ALCL cell lines to investigate differences between tumors expressing/not-expressing Anaplastic Lymphoma kinkase
A "Cartes d'Identite des Tumeurs" (CIT) project from the french Ligue Nationale Contre le Cancer (http://cit.ligue-cancer.net). Affymetrix UU133A gene expression data for a series of 32 cases of systemic Anaplastic Large Cell Lymphoma
(ALCL) and 5 ALCL cell lines; used to (1) confirm that tumors...
ORGANISM(S): Homo sapiens 
2007-05-05 | E-TABM-117 | biostudies-arrayexpress
TranscriptomicsMCL1 inhibitor induces apoptosis in Anaplastic Large Cell Lymphoma and in Primary Effusion Lymphoma
Overexpression of antiapoptotic BCL2 family proteins occurs in various hematologic malignanices and contributes to leukemogenesis by inhibiting the apoptotic machinery of the cells. BH3 mimetics provide an option for medication, with venetoclax as the first drug applied for chronic lymphocytic leuke...
ORGANISM(S): Homo sapiens 
2021-12-31 | E-MTAB-10903 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human large cell anaplastic lymphoma and classical Hodgkin lymphoma
Analysis of differential gene expression in human non-Hodgkin`s lymphoma cell lines and a primary leukaemic tumor sample of large cell anaplastic type in comparison with Hodgkin`s lymphoma cell lines and other non-Hodgkin`s lymphoma samples and non-neoplastic lymphocytes Experiment Overall Design: S...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-4109 | biostudies-arrayexpress
TranscriptomicsEffect of ALK kinase inhibitor, ceritinib, on the gene expression profile of SUDHL-1 cell line
Tyrosine kinase receptor anaplastic lymphoma kinase (ALK) is physiologically expressed during embryogenesis. However, chromosomal rearrangements, especially translocations, cause expression of pathogenic ALK fusion proteins that drive tumor formation and maintenance. For instance, the translocation ...
ORGANISM(S): Homo sapiens 
2026-01-01 | E-MTAB-15866 | biostudies-arrayexpress
TranscriptomicsIdentification of C/EBPβ Target Genes in ALK+ Anaplastic Large Cell Lymphoma (ALCL) by Gene Expression Profiling and Chromatin Immunoprecipitation
C/EBPβ (CCAAT enhancer binding protein) is a transcription factor that plays a crucial role in survival and transformation of ALK+ anaplastic large cell lymphoma (ALCL). The aim of this study was to identify the downstream targets of C/EBPβ responsible for ALK-mediated oncogenesis. C/EBPβ was knocke...
ORGANISM(S): Homo sapiens 
2013-07-10 | E-GEOD-23368 | biostudies-arrayexpress
TranscriptomicsGenomic profiling of Anaplastic Large Cell Lymphoma
Anaplastic Large Cell Lymphoma (ALCL) is a mature T-cell lymphoma that can present as a systemic or primary cutaneous disease. Systemic ALCL represents 2-5% of adult lymphoma but up to 30% of all pediatric cases. Two subtypes of systemic ALCL are currently recognized on the basis of the presence of ...
ORGANISM(S): Homo sapiens 
2013-09-20 | E-GEOD-50253 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of biopsy samples from peripheral T-cell lymphoma (PTCL)
Molecular signatures to improve diagnosis in PTCL and prognostication in angioimmunoblastic T-cell lymphoma (AITL). Gene expression profiling of PTCL patient samples was performed to investigate whether molecular signatures can be used to identify distinct entities of PTCL. Gene expression profiling...
ORGANISM(S): Homo sapiens 
2010-02-27 | E-GEOD-19069 | biostudies-arrayexpress
ProteomicsPhosphoproteome of NSCLC patient–derived cells.
Phosphoproteome of anaplastic lymphoma kinase–positive non-small cell lung cancer (ALK+ NSCLC) patient–derived cells.
ORGANISM(S): Homo Sapiens (human) 
2024-11-19 | PXD050973 | JPOST Repository
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