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TranscriptomicsTranscription profiling of human anaplastic large cell lymphoma cell lines - kinase signature
Anaplastic Large Cell Lymphomas (ALCL) represent a subset of lymphomas in which the Anaplastic Lymphoma Kinase (ALK) gene is frequently fused to the NPM gene. We previously demonstrated that the constitutive phosphorylation of ALK chimeric proteins is sufficient to induce cellular transformation in ...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6184 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of 32 human Anaplastic Large Cell Lymphomas (ALCL) and 5 ALCL cell lines to investigate differences between tumors expressing/not-expressing Anaplastic Lymphoma kinkase
A "Cartes d'Identite des Tumeurs" (CIT) project from the french Ligue Nationale Contre le Cancer (http://cit.ligue-cancer.net). Affymetrix UU133A gene expression data for a series of 32 cases of systemic Anaplastic Large Cell Lymphoma
(ALCL) and 5 ALCL cell lines; used to (1) confirm that tumors...
ORGANISM(S): Homo sapiens 
2007-05-05 | E-TABM-117 | biostudies-arrayexpress
TranscriptomicsRNA-seq of Breast Implant-Associated Anaplastic Large Cell Lymphoma
Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is an anaplastic lymphoma kinase-negative (ALKneg) T-cell lymphoma. Here, we provide RNA-seq data of four BIA-ALCL and four ALCL cell lines:TLBR-1, TLBR-2, TLBR-3, TLBR-4 and DEL (two replicates), KARPAS-299, KI-JK, SUP-M2 (two repl...
ORGANISM(S): Homo sapiens 
2025-01-14 | E-MTAB-14735 | biostudies-arrayexpress
TranscriptomicsEffect of ALK kinase inhibitor, ceritinib, on the gene expression profile of SUDHL-1 cell line
Tyrosine kinase receptor anaplastic lymphoma kinase (ALK) is physiologically expressed during embryogenesis. However, chromosomal rearrangements, especially translocations, cause expression of pathogenic ALK fusion proteins that drive tumor formation and maintenance. For instance, the translocation ...
ORGANISM(S): Homo sapiens 
2026-01-01 | E-MTAB-15866 | biostudies-arrayexpress
TranscriptomicsXenografts and lung metastases derived from neuroblastoma cell lines overexpressing Anaplastic lymphoma kinase (ALK) variants engrafted in immunodeficient mice
Neuroblastoma cell lines genetically modified to overexpress Anaplastic lymphoma kinase (ALK) point mutations or the ALK wild-type isoform were injected subcutaneously or orthotopically into NOD-SCID-gamma or athymic Swiss nude mice, respectively. After development of the tumor, RNA was extracted fr...
ORGANISM(S): Mus musculus 
2026-10-19 | E-MTAB-15992 | biostudies-arrayexpress
TranscriptomicsExpression of SUDHL-1 cell line treated by ALK inhibitors
In this study we compared the effects of ALK inhibitor on the gene expression, activation of cell signaling pathways, and functional properties of cells derived from a patient with Anaplastic Large Cell Lymphoma. we used microarrays to map the genome-wide gene expression patterns in ALK+TCL cells in...
ORGANISM(S): Homo sapiens 
2013-10-31 | E-GEOD-50803 | biostudies-arrayexpress
TranscriptomicsIdentification of C/EBPβ Target Genes in ALK+ Anaplastic Large Cell Lymphoma (ALCL) by Gene Expression Profiling and Chromatin Immunoprecipitation
C/EBPβ (CCAAT enhancer binding protein) is a transcription factor that plays a crucial role in survival and transformation of ALK+ anaplastic large cell lymphoma (ALCL). The aim of this study was to identify the downstream targets of C/EBPβ responsible for ALK-mediated oncogenesis. C/EBPβ was knocke...
ORGANISM(S): Homo sapiens 
2013-07-10 | E-GEOD-23368 | biostudies-arrayexpress
ProteomicsPhosphoproteome of NSCLC patient–derived cells.
Phosphoproteome of anaplastic lymphoma kinase–positive non-small cell lung cancer (ALK+ NSCLC) patient–derived cells.
ORGANISM(S): Homo Sapiens (human) 
2024-11-19 | PXD050973 | JPOST Repository
TranscriptomicsTranscription profiling of human large cell anaplastic lymphoma and classical Hodgkin lymphoma
Analysis of differential gene expression in human non-Hodgkin`s lymphoma cell lines and a primary leukaemic tumor sample of large cell anaplastic type in comparison with Hodgkin`s lymphoma cell lines and other non-Hodgkin`s lymphoma samples and non-neoplastic lymphocytes Experiment Overall Design: S...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-4109 | biostudies-arrayexpress
TranscriptomicsAnaplastic lymphoma kinase (ALK) inhibitor response in neuroblastoma is highly correlated with ALK mutation status, ALK mRNA and protein levels.
High anaplastic lymphoma kinase (ALK) protein levels may be correlated with an unfavorable prognosis in neuroblastoma (NBL) patients, regardless of ALK mutation status. We therefore examined the correlation between levels of ALK, phosphorylated ALK (pALK) and downstream signaling proteins and respon...
ORGANISM(S): Homo sapiens 
2011-07-07 | E-GEOD-22771 | biostudies-arrayexpress
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