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ProteomicsAncistrocladinium A induces cell death in drug-resistant myeloma cells via targeting transcription and RNA splicing machinery and ATF4-dependent apoptotic pathway: a promising candidate as a drug for multiple myeloma
N,C-coupled naphthylisoquinoline alkaloids like the natural product ancistrocladinium A, was known for its strong antiprotozoal activity, but had never explored for its antitumor activity. We found the alkaloid to be a very efficient anti-myeloma agent in various cell lines, including proteasome inh...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD043261 | Pride
Ancistrocladinium a Carfilzomib Rna splicing Panobinostat Nanolc-ms/ms Multiple myeloma Proteasome inhibitor resistance 
UnknownAncistrocladinium A Induces Apoptosis in Proteasome Inhibitor-Resistant Multiple Myeloma Cells: A Promising Therapeutic Agent Candidate.
Not available
S-EPMC10459547 | biostudies-literature
GenomicsAncistrocladinium A modulates RNA splicing, cellular stress response and induces cell death in proteasome inhibi-tor-resistant multiple myeloma cells: A promising therapeutic agent candidate
Ancistrocladinium A modulates RNA splicing, cellular stress response and induces cell death in proteasome inhibi-tor-resistant multiple myeloma cells: A promising therapeutic agent candidate
PRJNA991638 | ENA
TranscriptomicsAncistrocladinium A modulates RNA splicing, cellular stress response and induces cell death in proteasome inhibi-tor-resistant multiple myeloma cells: A promising therapeutic agent candidate
Analysis of gene expression alterations and RNA splicing events after Ancistrocladinium A treatment of INA-6 multiple myeloma cell line Ancistrocladinium A inan N,C-coupled naphthylisoquinoline alkaloid was analyzed for its ability to act as efficient anti-myeloma agent. The mode of action was unkno...
ORGANISM(S): Homo sapiens 
2023-08-30 | GSE236602 | GEO
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