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TranscriptomicsDifferential gene expression in neuroblastoma cells after treatment with vehicle control, JQ1, panobinostat, or combination of JQ1 and panobinostat
The bromodomain inhibitor JQ1 and the histone deacetylase inhibitor panobinostat induce synergistic anticancer effects We analyzed whether JQ1 and panobinostat synergistically modulate gene expression Neuroblastoma SK-N-BE(2) cells were treated with vehicle control, 1 microM JQ1, 10 nM panobinostat,...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-68690 | biostudies-arrayexpress
TranscriptomicsRNAseq to investigate transcriptional changes in human MM cell lines due to panobinostat, 5-Azacytidine, panobinostat+5-Azacytidine or n-methyl-2-pyrroldine (NMP) treatments.
Purpose: We applied RNA sequencing technology for high-throughput analysis of transcriptional changes within human MM cell lines JJN3 and U266 due to individual and combination drug treatment. Methods: JJN3 and U266 cells were treated with pan-HDACi panbobinostat, DNMTi 5-Azacytidine, panobinostat+5...
ORGANISM(S): Homo sapiens 
2014-04-09 | E-GEOD-56623 | biostudies-arrayexpress
TranscriptomicsStudy of gene expression changes in TH-MYCN murine neuroblastomas in response to 24hr of panobinostat treatment
Neuroblastoma is the most common extra-cranial malignancy in childhood and accounts for approximately 15% of childhood cancer deaths. Amplification of N-Myc in neuroblastoma is associated with aggressive disease and predicts for poor prognosis. Novel therapeutic approaches are therefore essential to...
ORGANISM(S): Mus musculus 
2015-07-15 | E-GEOD-69869 | biostudies-arrayexpress
ProteomicsProtocol for performing and analyzing TPP-TR and TPP-CCR experiments
Explore the effect of Panobinostat on the thermal stability of the proteins of the K562 cell line proteome.
ORGANISM(S): Homo sapiens (Human) 
2019-05-24 | PXD013774 | Pride
Panobinostat Tpp-tr Tpp-ccr 
ClinicalPanobinostat in Treating Patients With Relapsed or Refractory Non-Hodgkin Lymphoma
Panobinostat may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. This phase II trial is studying how well panobinostat works in treating patients with relapsed or refractory non-Hodgkin lymphoma
2099626 | ecrin-mdr-crc
GenomicsGene Expression during Panobinostat Dosing
Gene Expression during Panobinostat Dosing
PRJNA432059 | ENA
TranscriptomicsAberrant chromatin acetylation in MLL-AF9 leukemia mediates the response to HDAC inhibition (microarray)
We investigated the response of acute myeloid cells (AML) expressing MLL-AF9 fusion gene to the pan-HDACi panobinostat (LBH589), and found that low conentrations of panobinostat lead to MLL-AF9 cell toxicity and rapid changes in gene expression. Human hematopoietic stem/progenitor cells (HSPC) expre...
ORGANISM(S): Homo sapiens 
2015-03-01 | E-GEOD-54218 | biostudies-arrayexpress
GenomicsBulk RNAseq of A375 cells treated with Panobinostat
Bulk RNAseq of A375 cells treated with Panobinostat
PRJNA607239 | ENA
GenomicsCombination of CBL0137 and Panobinostat in DIPG
Combination of CBL0137 and Panobinostat in DIPG
PRJNA642726 | ENA
GenomicsTranscriptomic analysis of LN229 cell treated by unit of bortezomib and panobinostat
Transcriptomic analysis of LN229 cell treated by unit of bortezomib and panobinostat
PRJNA853204 | ENA
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