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ProteomicsThermal Proteome Profiling Datasets for smarTPCA
Chemical biology and the application of small molecules has proven to be a potent perturbation strategy especially for the functional elucidation of proteins, their networks and regulators. In recent years, the cellular thermal shift assay (CETSA) and its proteome-wide extension, thermal proteome pr...
ORGANISM(S): Homo sapiens (Human) 
2022-06-09 | PXD032942 | Pride
Kinase inhibitors Small molecule arranged thermal proximity coaggregation (smartpca) Tpp with temperature range (tpp-tr) or compound concentration range (tpp-ccr) Hl-60 cell line Thermal proteome profiling (tpp) 
ProteomicsProtocol for performing and analyzing TPP-TR and TPP-CCR experiments
Explore the effect of Panobinostat on the thermal stability of the proteins of the K562 cell line proteome.
ORGANISM(S): Homo sapiens (Human) 
2019-05-24 | PXD013774 | Pride
Panobinostat Tpp-tr Tpp-ccr 
ProteomicsHepatocyte Proteome Destabilization and Novel Targets for PFASs Unveiled through Combined Thermal Proteome Profiling and Deep Transfer Learning
TPP-CCR (Thermal proteome profiling with compound concentration range TPP-CCR) identified key protein targets for three representative PFASs and a benchmark sample of staurosporine.
ORGANISM(S): Homo sapiens (Human) 
2026-05-13 | PXD059666 | Pride
UnknownSmall Molecule Arranged Thermal Proximity Coaggregation (smarTPCA)-A Novel Approach to Characterize Protein-Protein Interactions in Living Cells by Similar Isothermal Dose-Responses.
Not available
S-EPMC9147192 | biostudies-literature
ProteomicsThe Golgi stacking protein GRASP55 is targeted by the natural compound prodigiosin
The bacterial secondary metabolite prodigiosin has been shown to exert anticancer, antimalarial, antibacterial and immunomodulatory properties. With regard to cancer, it has been reported to affect cancer cells but not non-malignant cells, rendering prodigiosin a promising lead compound for anticanc...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD043247 | Pride
Prodigiosin  golgi apparatus  natural compound  autophagy  target identification 
UnknownCommon metabolic networks contribute to carbon sink strength of sorghum internodes: implications for bioenergy improvement.
Not available
S-EPMC6868837 | biostudies-literature
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