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ProteomicsProtocol for performing and analyzing TPP-TR and TPP-CCR experiments
Explore the effect of Panobinostat on the thermal stability of the proteins of the K562 cell line proteome.
ORGANISM(S): Homo sapiens (Human) 
2019-05-24 | PXD013774 | Pride
Panobinostat Tpp-tr Tpp-ccr 
ProteomicsThermal Proteome Profiling Datasets for smarTPCA
Chemical biology and the application of small molecules has proven to be a potent perturbation strategy especially for the functional elucidation of proteins, their networks and regulators. In recent years, the cellular thermal shift assay (CETSA) and its proteome-wide extension, thermal proteome pr...
ORGANISM(S): Homo sapiens (Human) 
2022-06-09 | PXD032942 | Pride
Kinase inhibitors Small molecule arranged thermal proximity coaggregation (smartpca) Tpp with temperature range (tpp-tr) or compound concentration range (tpp-ccr) Hl-60 cell line Thermal proteome profiling (tpp) 
ProteomicsThe Golgi stacking protein GRASP55 is targeted by the natural compound prodigiosin
The bacterial secondary metabolite prodigiosin has been shown to exert anticancer, antimalarial, antibacterial and immunomodulatory properties. With regard to cancer, it has been reported to affect cancer cells but not non-malignant cells, rendering prodigiosin a promising lead compound for anticanc...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD043247 | Pride
Prodigiosin  golgi apparatus  natural compound  autophagy  target identification 
UnknownGPMelt: A hierarchical Gaussian process framework to explore the dark meltome of thermal proteome profiling experiments.
Not available
S-EPMC11463780 | biostudies-literature
UnknownA TLR4-derived non-cytotoxic, self-assembling peptide functions as a vaccine adjuvant in mice.
Not available
S-EPMC6314143 | biostudies-literature
UnknownAdipogenic Effects and Gene Expression Profiling of Firemaster® 550 Components in Human Primary Preadipocytes.
Not available
S-EPMC5915190 | biostudies-literature
ProteomicsNew antiviral small molecule inhibitors disturb interactions between cellular HSP70 and virus proteins
RNA virus outbreaks such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV2), Ebola virus (EBOV) and Zika virus (ZIKV) causing worldwide health emergencies have highlighted the urgent need of new antiviral strategies. Upon outbreaks with new, unmet viruses where knowledge of virus biology...
ORGANISM(S): Homo sapiens (Human) Filoviridae Ebolavirus 
2021-01-04 | PXD021494 | Pride
Antiviral compound 2d-tpp Virus proteins Tpp Lc-msms 
ProteomicsComprehensive chemical proteomics for target deconvolution of the redox active drug auranofin
Chemical proteomics encompasses novel drug target deconvolution methods in which compound modification is not required. Herein we use Thermal Proteome Profiling, Functional Identification of Target by Expression Proteomics and multiplexed redox proteomics for deconvolution of auranofin targets to ai...
ORGANISM(S): Homo sapiens (Human) 
2020-03-19 | PXD016776 | Pride
Cancer Nfkb2 Mass spectrometry Hct116 Thioredoxin reductase Expression Chordc1 Database A375 Drug Proteomics Resource Rko Chemotherapeutic Auranofin Compound 
UnknownMachine learning-based phenotypic screening for postmitotic growth inducers uncover vitamin D3 metabolites as small molecule ribosome agonists.
Not available
S-EPMC9136510 | biostudies-literature
UnknownBreast imaging with ultra-low field MRI.
Not available
S-EPMC12921021 | biostudies-literature
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