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MetabolomicsBiological Effects of Amphiphilic Copolymer Nanoparticle-Encapsulated Multi-target Chemotherapeutic Drugs on MCF-7 Human Breast Cancer Cells
INTRODUCTION: Amphiphilic copolymer nanoparticle-encapsulated multi-target chemotherapeutic drugs have attracted considerable attention due to their favorable drug efficiency and potential application prospect. Studies have shown that an amphiphilic copolymer, methoxypoly(ethylene glycol)-poly(lacti...
2018-05-03 | MTBLS430 | MetaboLights
MetabolomicsControl of Topoisomerase II Activity and Chemotherapeutic Inhibition by TCA Cycle Metabolites
Not available
ORGANISM(S): Saccharomyces cerevisiae 
ST001658 | MetabolomicsWorkbench
TranscriptomicsTranscription profiling of mouse primary macrophages treated with the chemotherapeutic agent, 5,6-dimethylxanthenone-4-acetic acid,
Vascular disrupting agents (VDA) represent a novel approach to the treatment of cancer, resulting in collapse of tumor vasculature and tumor death. 5,6-Dimethylxanthenone-4-acetic acid (DMXAA) is a VDA currently in advanced Phase II clinical trials, yet its precise mechanism of action is unknown de...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7194 | biostudies-arrayexpress
GenomicsModeling cellular pliancy-dependent oncogene-induced signaling and chemotherapeutic response during breast tumorigenesis
Modeling cellular pliancy-dependent oncogene-induced signaling and chemotherapeutic response during breast tumorigenesis
PRJNA641791 | ENA
TranscriptomicsTranscription profiling of human lung cancer cell A549 lines treated with the chemotherapeutic drug motexafin gaolinium at 4, 12 and 24h timepoints
Human lung cancer (A549) cells were treated 50uM of the metal cation-containing chemotherapeutic drug motexafin gadolinium (MGd) for 4, 12, and 24 hrs and expression compared to control cells (treated with 5% mannitol for the same length of time)
ORGANISM(S): Homo sapiens 
2007-03-12 | E-GEOD-2189 | biostudies-arrayexpress
GenomicsTargeting the 3D genome by anthracyclines for chemotherapeutic effects
Targeting the 3D genome by anthracyclines for chemotherapeutic effects
PRJNA1154632 | ENA
GenomicsInfluence of substrate stiffness on chemotherapeutic response in breast cancer
Influence of substrate stiffness on chemotherapeutic response in breast cancer
PRJNA418945 | ENA
ProteomicsRNF25 provides tolerance towards chemotherapeutic mRNA damage
Many chemotherapeutic agents damage DNA, which is believed to mediate their therapeutic efficacy. However, most of these agents act pleiotropically and also damage RNA, raising questions about the contribution of RNA damage to therapeutic outcomes and whether cells possess factors that protect them ...
ORGANISM(S): Homo sapiens (Human) 
2026-03-14 | PXD059287 | Pride
Rna damage Gcn2 5azac Gcn1 Rnf25 
GenomicsIdentification of the primary target of the chemotherapeutic agent CX-5461 as a late step in transcription initiation by RNA Polymerase I
In recent years, several small molecule cytotoxic drugs have been identified as potential inhibitors of ribosome biogenesis (Drygin et al., 2011; Peltonen et al., 2014a; Peltonen et al., 2014b). CX-5461 is one such drug that has also demonstrated anticancer potential for a wide range of malignancies...
ORGANISM(S): Mus musculus 
2021-04-07 | E-MTAB-9242 | biostudies-arrayexpress
GenomicsDisrupting SOX2 Self-Association and Condensates to Overcome Chemotherapeutic Drug Resistance in Lung Squamous Cell Carcinoma [RNA-Seq]
Disrupting SOX2 Self-Association and Condensates to Overcome Chemotherapeutic Drug Resistance in Lung Squamous Cell Carcinoma [RNA-Seq]
PRJNA1220703 | ENA
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