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ProteomicsThe E3 ubiquitin ligase RNF25 protects stalled DNA replication forks
Cancer cells experience high levels of replication stress and have therefore adapted mechanisms to tolerate replication stress. Using a CRISPR screen, we identified RNF25 as a mediator of replication stress tolerance in cancer cells. RNF25-ablation results in ssDNA accumulation, decreased replicatio...
ORGANISM(S): Homo sapiens (Human) 
2025-06-30 | PXD056698 | Pride
Cell culture Ip-ms Homo sapiens 
ProteomicsRNF25-Mediated NF-κB Activation Drives Anti-Apoptosis and Therapy Resistance in Cancer
Dysregulation of the NF-κB pathway is frequently observed in cancers, where it contributes to therapy resistance by inhibiting apoptosis. Mass spectrometry (MS)-based proteomics were employed to identify factors associated with the anti-apoptotic process. We identify RNF25, an E3 ubiquitin ligase, a...
ORGANISM(S): Homo Sapiens 
2025-03-05 | PXD061521 |
ProteomicsRNF25 provides tolerance towards chemotherapeutic mRNA damage
Many chemotherapeutic agents damage DNA, which is believed to mediate their therapeutic efficacy. However, most of these agents act pleiotropically and also damage RNA, raising questions about the contribution of RNA damage to therapeutic outcomes and whether cells possess factors that protect them ...
ORGANISM(S): Homo sapiens (Human) 
2026-03-14 | PXD059287 | Pride
Rna damage Gcn2 5azac Gcn1 Rnf25 
GenomicsRNF25-Mediated NF-κB Activation Drives Anti-Apoptosis and Therapy Resistance in Cancer
RNF25-Mediated NF-κB Activation Drives Anti-Apoptosis and Therapy Resistance in Cancer
PRJNA1232002 | ENA
GenomicsRNF25-Mediated NF-κB Activation Drives Anti-Apoptosis and Therapy Resistance in Cancer [ChIP-seq]
RNF25-Mediated NF-κB Activation Drives Anti-Apoptosis and Therapy Resistance in Cancer [ChIP-seq]
PRJNA1242338 | ENA
TranscriptomicsRNF25-Mediated NF-κB Activation Drives Anti-Apoptosis and Therapy Resistance in Cancer
Dysregulation of the NF-κB pathway is frequently observed in cancers, contributing to therapy resistance by inhibiting apoptosis. In this study, we identify RNF25, an E3 ubiquitin ligase, as a key regulator of signal transduction, inflammation, immune responses, and apoptosis. RNA sequencing (RNA-se...
ORGANISM(S): Homo sapiens 
2025-03-25 | GSE291116 | GEO
UnknownOxidative Stress Promotes Liver Cancer Metastasis via RNF25-Mediated E-Cadherin Protein Degradation.
Not available
S-EPMC10987140 | biostudies-literature
GenomicsRNF25-Mediated NF-κB Activation Drives Anti-Apoptosis and Therapy Resistance in Cancer [ChIP-seq]
Dysregulation of the NF-κB pathway is frequently observed in cancers, contributing to therapy resistance by inhibiting apoptosis. In this study, we identify RNF25, an E3 ubiquitin ligase, as a key regulator of signal transduction, inflammation, immune responses, and apoptosis. RNA sequencing (RNA-se...
ORGANISM(S): Homo sapiens 
2025-03-26 | GSE293002 | GEO
UnknownThe RING Finger E3 Ligase RNF25 Protects DNA Replication Forks Independently of its Canonical Roles in Ubiquitin Signaling.
Not available
S-EPMC11741350 | biostudies-literature
UnknownThe RING finger E3 ligase RNF25 protects DNA replication forks independently of its canonical roles in ubiquitin signaling.
Not available
S-EPMC12325937 | biostudies-literature
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