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TranscriptomicsEntamoeba histolytica and auranofin treatment
2 million E. histolytica HM1:IMSS was treated with 0.5% DMSO for 3 h and 2 million E. histolytica HM1:IMSS was treated with 1 M-5M auranofin for 3 h
ORGANISM(S): Entamoeba histolytica 
2012-02-03 | E-MEXP-3494 | biostudies-arrayexpress
ProteomicsAuranofin Fosters Regulatory T Cell Expansion and Augmented Tumor Burden in Mice
Auranofin, an FDA-approved antirheumatic drug, has been reported to have anti-tumoral properties but its immunological effects and significance are not well understood. This study is the first to report auranofin-induced regulatory T cell (Treg) expansion. In a mouse model with B16F10 melanoma, aura...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-08 | PXD060423 | Pride
Thioredoxin reductase 1 (trxr1) Nrf2 Immune response Treg B16f10 Auranofin 
ProteomicsNovel insights into redox-based mechanisms for auranofin- induced rapid cancer cell death
One of the significant features of cancer cells is a persistent pro-oxidative status. Therefore, compared to their normal counterparts, the malignant cells are generally more dependent on antioxidants for cell survival and more vulnerable to further oxidative insults via pharmacolog-ical interventio...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD036558 | Pride
Auranofin  oxidative stress  redox regulation  redoxome  cancer 
ProteomicsComprehensive chemical proteomics for target deconvolution of the redox active drug auranofin
Chemical proteomics encompasses novel drug target deconvolution methods in which compound modification is not required. Herein we use Thermal Proteome Profiling, Functional Identification of Target by Expression Proteomics and multiplexed redox proteomics for deconvolution of auranofin targets to ai...
ORGANISM(S): Homo sapiens (Human) 
2020-03-19 | PXD016776 | Pride
Cancer Nfkb2 Mass spectrometry Hct116 Thioredoxin reductase Expression Chordc1 Database A375 Drug Proteomics Resource Rko Chemotherapeutic Auranofin Compound 
ProteomicsAuranofin Fosters Regulatory T Cell Expansion and Augmented Tumor Burden in Mice
Auranofin, an FDA-approved antirheumatic drug, has been reported to have anti-tumoral properties but its immunological effects and significance are not well understood. This study is the first to report auranofin-induced regulatory T cell (Treg) expansion. In a mouse model with B16F10 melanoma, aura...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-08 | PXD069997 | Pride
Mouse model Treg Auranofin 
ProteomicsAuranofin targets UBA1 and enhances UBA1 activity by facilitating ubiquitin trans-thioesterificlation to E2 ubiquitin-conjugating enzymes
UBA1 is the primary E1 ubiquitin-activating enzyme, regulating stability and function of numerous proteins via initiating their ubiquitination. Decreased or insufficient ubiquitination can cause or drive aging and many deadly diseases. Therefore, a small-molecule UBA1 activity enhancer could have br...
ORGANISM(S): Homo sapiens (Human) 
2023-07-10 | PXD042558 | Pride
Ubiquitination Uba1 Auranofin 
TranscriptomicsTranscriptome analysis of Candida albicans treated with auranofin
Candida albicans lab strain SC5314 was grown in YPD broth at 30C°C from OD=66=0.1 till 1.0. The culture was divided into two batches. One batch was treated with 16 μg/mL auranofin. The other batch was treated with the same volume of vehicle (DMSO). After three hours, cells were harvested for RNA-Seq...
ORGANISM(S): Candida albicans 
2026-04-30 | E-MTAB-16895 | biostudies-arrayexpress
GenomicsAuranofin prevents liver fibrosis by system Xc-mediated inhibition of NLRP3 inflammasome
Auranofin prevents liver fibrosis by system Xc-mediated inhibition of NLRP3 inflammasome
PRJNA735867 | ENA
GenomicsTranscriptome analysis of Candida albicans treated with auranofin
Transcriptome analysis of Candida albicans treated with auranofin
PRJEB111461 | ENA
ProteomicsRedox Proteomics Analysis of Auranofin Exposed Ovarian Cancer Cells
The effects of Auranofin (AF) on protein expression and protein oxidation in A2780 cancer cells were explored through a robust investigative strategy based on joint expression proteomics and redox proteomics determinations. Bioinformatics analysis of the proteomics data supports the view that the mo...
ORGANISM(S): Homo sapiens (Human) 
2022-05-19 | PXD028681 | Pride
Cysteine Auranofin Gold Ovarian cancer Redox proteomics 
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