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TranscriptomicsGene expression profiling of mouse bone marrow-derived macrophages (RNA-Seq)
Bone marrow (BM) cells were obtained by flushing the long bones of 8-week old C57BL/6 mice. BM cells were then were plated in macrophage SFM medium (Life Technologies) supplemented with penicillin-streptomycin and CSF-1 (Peprotech, 100 ng/ml) and cultured for one week to allow macrophage differenti...
ORGANISM(S): Mus musculus 
2014-11-01 | E-GEOD-58283 | biostudies-arrayexpress
UnknownAsymptomatic Hyperuricemia Promotes Recovery from Ischemic Organ Injury by Modulating the Phenotype of Macrophages.
Not available
S-EPMC8869798 | biostudies-literature
UnknownNo NLRP3 inflammasome activity in kidney epithelial cells, not even when the NLRP3-A350V Muckle-Wells variant is expressed in podocytes of diabetic mice.
Not available
S-EPMC10513077 | biostudies-literature
TranscriptomicsPKC-dependent MYRF dysregulation links Aβ pathology to oligodendrocyte, myelin and cognitive alterations in Alzheimer’s disease
Alzheimer’s disease (AD) is characterized not only by neuronal loss and synaptic dysfunction but also by emerging evidence of oligodendrocyte and myelin pathology. Amyloid-β (Aβ), a hallmark of AD, disrupts oligodendrocyte homeostasis through mechanisms that remain poorly understood. Here, we invest...
ORGANISM(S): Mus musculus 
2025-12-31 | E-MTAB-16400 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of tumor-associated macrophages (TAMs) overexpressing miR-511-3p
Hematopoietic stem/progenitor cells (HS/PCs) were transduced with lentiviral vectors overexpressing OFP and either miR-511-3p or a control, mutated miRNA sequence (miR-511-3p-mut). The transduced HS/PCs were then transplanted in recipient C57BL/6 mice. Tumors (Lewis lung carcinomas, LLC) were inject...
ORGANISM(S): Mus musculus 
2012-04-01 | E-GEOD-34903 | biostudies-arrayexpress
TranscriptomicsNuclear Lamins are Not Required for Genome Organization in Mouse Embryonic Stem Cells [RNA-Seq]
In mammals, the nuclear lamina interacts with hundreds of large genomic regions, termed lamina-associated domains (LADs) that are generally in a transcriptionally repressed state. Lamins form the major structural component of the lamina and have been reported to bind DNA and chromatin. Here we syste...
ORGANISM(S): Mus musculus 
2015-03-10 | E-GEOD-62684 | biostudies-arrayexpress
UnknownTubular cell polyploidy protects from lethal acute kidney injury but promotes consequent chronic kidney disease.
Not available
S-EPMC9532438 | biostudies-literature
UnknownTubular Epithelial Cell HMGB1 Promotes AKI-CKD Transition by Sensitizing Cycling Tubular Cells to Oxidative Stress: A Rationale for Targeting HMGB1 during AKI Recovery.
Not available
S-EPMC10103235 | biostudies-literature
UnknownReverse Phenotyping after Whole-Exome Sequencing in Steroid-Resistant Nephrotic Syndrome.
Not available
S-EPMC6946071 | biostudies-literature
UnknownDifferentiation of crescent-forming kidney progenitor cells into podocytes attenuates severe glomerulonephritis in mice.
Not available
S-EPMC7614034 | biostudies-literature
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