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TranscriptomicsMolecular classification of human cholangiocarcinoma
Transcriptomic profiling Background Cholangiocarcinoma accounts for 5-10% of primary hepatic cancers. The etiology is unclear and patients are often diagnosed without risk factors. Resection is the only curative treatment although patients frequently remain undiagnosed until advanced stage of disea...
ORGANISM(S): Homo sapiens 
2012-02-25 | E-GEOD-26566 | biostudies-arrayexpress
TranscriptomicsEffect of HDAC2 siRNA on HCC
Determine the effect and specificity of HDAC2 siRNA compared to SAHA inhibition of HDAC2 in hepatocellular carcinoma (HCC) Profile of treated cells compared to control Transcriptomic profiling
ORGANISM(S): Homo sapiens 
2014-10-02 | E-GEOD-52232 | biostudies-arrayexpress
ProteomicsHeLa proteome of 12,250 protein-coding genes
We developed an optimized multi-shot proteomics workflow based on high-resolution offline high pH reversed-phase peptide separation of high peptide loads collecting many fractions that were in turn analyzed by short online chromatographic separations and fast peptide sequencing using orbitrap tandem...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000081563 | MassIVE
TranscriptomicsProfiling of hepatic progenitor cells isolated from Egfr fl/fl and Met fl/fl murine control livers
Transcriptomic profiling; Determination of the transcriptomic similarity between Egfr fl/fl and Met fl/fl progenitor cells isolated from excised livers (n=3, each) Profiling of hepatic progenitor cells
ORGANISM(S): Mus musculus 
2013-09-05 | E-GEOD-46981 | biostudies-arrayexpress
ProteomicsDissection of prognostic traits in colorectal cancer using multi-dimensional proteomics
Colorectal cancer (CRC) is the third most commonly diagnosed cancer worldwide and the second leading cause of cancer death globally. The molecular mechanisms underlying CRC have been investigated using different omics technologies including genomics, proteomics, and metabolomics. Resulting molecular...
ORGANISM(S): Homo sapiens (Human) 
2025-03-26 | PXD044246 | Pride
Proteomics Colorectal cancer Phosphoproteomics 
TranscriptomicsmTOR inhibitors synergistically induce regression, reversal of gene expression and autophagy in hepatocellular carcinoma
The mTOR-allosteric inhibitor, RAD001, in combination with a PI3K/mTOR ATP-site competitive inhibitor, BEZ235, causes gene reprogramming, autophagy and tumor regression, in a mouse model approximating human HCC with poor prognosis, leading to an investigator Phase 1B-2 clinical trial. Comparative st...
ORGANISM(S): Mus musculus 
2012-07-11 | E-GEOD-37129 | biostudies-arrayexpress
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