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TranscriptomicsRNA-seq of human fibroblast cell cultures treated with resveratrol against DMSO treated controls, with and without siRNA treatment targeting SIRT1
Resveratrol (RSV) is a small compound with many reported beneficial effects, including increased expression of genes involved in inborn errors of metabolism. We wanted to investigate the effects of RSV on gene regulation on a global scale in order to detect new target genes for RSV mediated up-regul...
ORGANISM(S): Homo sapiens 
2018-11-12 | E-MTAB-7360 | biostudies-arrayexpress
TranscriptomicsGene expression microarray analysis of rat nasal tissue with time and dose following formaldehyde inhalation
Formaldehyde (FA), an endogenous cellular aldehyde, is a rat nasal carcinogen. In this study, concentration- and exposure-duration transitions in FA mode of action (MOA) were examined with pharmacokinetic (PK) modeling for tissue formaldehyde acetal (FAcetal) and glutathione (GSH) and with histopath...
ORGANISM(S): Rattus norvegicus 
2010-07-28 | E-GEOD-23179 | biostudies-arrayexpress
TranscriptomicsStudies on the production of fungal polyketides in Aspergillus nidulans using systems biology tools
Using genetic engineering tools available for the model organism Aspergillus nidulans, we constructed two recombinant strains; one expressing the model polyketide Penicillium griseofulvum 6-methylsalicylic acid (6-MSA) polyketide synthase gene, and one expressing the 6-MSA gene and overexpressing th...
ORGANISM(S): Emericella nidulans 
2009-02-27 | E-GEOD-12859 | biostudies-arrayexpress
TranscriptomicsMolecular anatomy of gene expression responses in stressed hepatocytes
It is well-known that isolation and cultivation of primary hepatocytes causes major gene expression alterations. In the present genome-wide, time resolved study of cultivated human and mouse hepatocytes, we made the observation that expression changes in culture strongly resemble alterations in live...
ORGANISM(S): Mus musculus 
2016-09-28 | E-MTAB-4444 | biostudies-arrayexpress
TranscriptomicsRNA-seq of spinal cord, brain, liver, and muscle from an SMA mouse model
This study describes RNA-seq results from total spinal cord, brain, liver and muscle samples taken at PND1 and PND5 from an SMA mouse model paired with samples taken from heterozygous litter-mates. There are four mouse in each group.
ORGANISM(S): Mus musculus 
2016-08-25 | E-MTAB-3664 | biostudies-arrayexpress
TranscriptomicsRNA-seq of livers from glucagon receptor knock-out (GcgrKO) mice compared to wildtype littermates
Glucagon is a key regulator of glucose homeostasis, amino acid catabolism, and lipid metabolism. Glucagon receptor knock-out (GcgrKO) mice have slightly reduced blood glucose levels whereas plasma levels of amino acids are vastly increased reflecting disruption of hepatic amino acid catabolism. To d...
ORGANISM(S): Mus musculus 
2022-10-11 | E-MTAB-12060 | biostudies-arrayexpress
ProteomicsPhospho-networks in Ovarian Cancer Cell Lines
Cancer cells acquire pathological phenotypes through accumulation of mutations that perturb signaling processes. While thousands of mutations have been identified, mostly by genome-wide sequencing, systematic interpretation of their role in cancer and impact on cellular information processing is pre...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-28 | MSV000080700 | MassIVE
TranscriptomicsDistinct molecular signatures of mild extrinsic and intrinsic atopic dermatitis
Atopic dermatitis (AD) is a common inflammatory skin disease with underlying defects in epidermal function and immune responses. The goal of this study was to investigate differences in gene expression in lesional skin from patients with mild extrinsic or intrinsic AD compared to skin from healthy c...
ORGANISM(S): Homo sapiens 
2016-03-08 | E-GEOD-75890 | biostudies-arrayexpress
UnknownUpdate on the third international stroke trial (IST-3) of thrombolysis for acute ischaemic stroke and baseline features of the 3035 patients recruited.
Not available
S-EPMC3286387 | biostudies-literature
UnknownSARS-CoV-2 Viral Load in the Nasopharynx at Time of First Infection Among Unvaccinated Individuals: A Secondary Cross-Protocol Analysis of 4 Randomized Trials.
Not available
S-EPMC11117088 | biostudies-literature
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