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UnknownPhase I study of quizartinib administered daily to patients with relapsed or refractory acute myeloid leukemia irrespective of FMS-like tyrosine kinase 3-internal tandem duplication status.
Not available
S-EPMC3804291 | biostudies-literature
GenomicsGenotype and exome data for an Australian Aboriginal population: a reference panel for health-based research
Genetic analyses, including genome-wide association studies and whole exome sequencing (WES), provide powerful tools for the analysis of complex and rare genetic diseases. To date there are no reference data for Aboriginal Australians to underpin the translation of health-based genomic research. Her...
EGAS00001001585 | EGA
Genomicsena-DATASET-TKI_AGHS-05-11-2015-15:26:51:621-176 - samples
Genotype and exome data for an Australian Aboriginal population: a reference panel for health-based research.
EGAD00001001661 | EGA
GenomicsIllumina_HumanOmni2.5 - samples
Genotyped samples using Illumina HumanOmni2.5
EGAD00010000652 | EGA
GenomicsFirst genome-wide association study in an Australian Aboriginal population provides insights into genetic risk factors for Body Mass Index and Type 2 Diabetes
A body mass index (BMI) >22kg/m2 is a risk factor for type 2 diabetes (T2D) in Aboriginal Australians. To identify loci associated with BMI and T2D we undertook a genome-wide association study using 1,355,133 quality-controlled single nucleotide polymorphisms (SNPs) genotyped (Illumina 2.5M Duo Bea...
EGAS00001001004 | EGA
GenomicsAboriginal Genetics and Health Studies based at the Telethon Kids Institute, Perth, Western Australia
Data Access Committee EGAC00001000261
EGAC00001000261 | EGA
TranscriptomicsUV-irradiation of skin enhances glycolytic flux in bone marrow-differentiated dendritic cells
Following UV irradiation of skin, dendritic cells (DCs) differentiating from the bone marrow (BM) of mice have a reduced ability to prime new immune responses; their reduced immunogenicity is maintained for at least 16 weeks in UV-chimeric mice. We hypothesized that different metabolic states underp...
ORGANISM(S): Mus musculus 
2015-10-30 | E-GEOD-74468 | biostudies-arrayexpress
GenomicsNHLBI Family Heart Study (FamHS-Visit1 and FamHS-Visit2)

The Family Heart Study (FamHS) was funded by the National Heart, Lung, and Blood Institute (NHLBI). It was begun in 1992 with the ascertainment of 1,200 families, half randomly sampled, and half selected because of an excess of coronary heart disease (CHD) or risk factor abnormalities as compared...

phs000221.v1.p1 | EGA
TranscriptomicsHypoxia-inducible factor (Hif)-1 knockdown blocks tumor growth, myeloma-induced angiogenesis and bone destruction in vivo
In multiple myeloma (MM), hypoxia-inducible transcription factor-1 (HIF-1) is overexpressed in the MM cells of the hypoxic bone marrow (BM) microenvironment. Herein, we explored in MM cells the in vitro and in vivo effects of persistent HIF-1 inhibition by expression of a lentivirus shRNA pool on pr...
ORGANISM(S): Homo sapiens 
2013-04-01 | E-GEOD-40326 | biostudies-arrayexpress
UnknownCognitive function and retinal and ischemic brain changes: the Women's Health Initiative.
Not available
S-EPMC3310310 | biostudies-literature
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