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UnknownGenotype-guided tamoxifen dosing increases active metabolite exposure in women with reduced CYP2D6 metabolism: a multicenter study.
Not available
S-EPMC3158597 | biostudies-literature
TranscriptomicsWhole Genome Sequencing Informs Therapeutic Selection for Pancreatic Cancer
Pancreatic cancer remains one of the most lethal of malignancies and a major health burden. We performed whole genome sequencing and CNV analysis of 100 pancreatic ductal adenocarcinomas. Chromosomal rearrangements leading to gene disruption were frequent, affecting genes known to be important in pa...
ORGANISM(S): Homo sapiens 
2015-02-27 | E-GEOD-61502 | biostudies-arrayexpress
GenomicsGenomic catastrophes frequently arise in esophageal adenocarcinoma and drive tumorigenesis.
Oesophageal adenocarcinoma (EAC) incidence is rapidly increasing in Western countries. A better understanding of EAC underpins efforts to improve early detection and treatment outcomes. While large EAC exome sequencing efforts to date have found recurrent loss-of-function mutations, oncogenic drivin...
EGAS00001000750 | EGA
GenomicsQCMG_20140410_OESO - samples
Description not provided
EGAD00001000845 | EGA
GenomicsWhole Genome Sequencing of Esophageal Adenocarcinomas DAC
Data Access Committee EGAC00001000192
EGAC00001000192 | EGA
GenomicsRNASeq_PACA-AU_Apr_2017 - samples
BAM outputs from RSEM (https://deweylab.github.io/RSEM/) analysis of RNASeq sequencing on HiSeq platform of tumour samples from 95 pancreatic adenocarcinoma cases.
EGAD00001003298 | EGA
GenomicsICGC Benchmark 1 (CLL) - samples
Raw fastq files from WGS sequencing of CLL and matching blood normal for the ICGC Techval Benchmark1 study. Sequence data was provided to multiple centers for independent analysis and comparison.
EGAD00001001858 | EGA
GenomicsICGC Benchmark 2 (Medulloblastoma) - samples
Raw fastq files for sequence data generated at 5 sequencing centers from a Medulloblastoma sample and matching blood normal control.
EGAD00001001859 | EGA
GenomicsA comprehensive assessment of somatic mutation detection in cancer using whole genome sequencing
As whole genome sequencing for cancer genome analysis becomes a clinical tool, a full understanding of the variables affecting sequencing analysis output is required. Using tumor-normal sample pairs from two different types of cancer, chronic lymphocytic leukemia and medulloblastoma, we conducted a ...
EGAS00001001539 | EGA
GenomicsGenome Sequencing of Pancreatic Ductal Adenocarcinoma at The Human Genome Sequencing Center of Baylor College of Medicine (HGSC-BCM)

Pancreatic ductal adenocarcinomas (PDAC) is the 11th most common cancer in the USA but the 4th in fatalities. The onset and progression of cancer is driven by extensive rearrangement and mutation of the genome. We combined our capability to capture and enrich exome DNA with the next generation se...

phs000516.v1.p1 | EGA
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