Sort   by:  
 Page size 
TranscriptomicsMicroglial response to A? and prostaglandin-E2 EP4 receptor activation
A persistent and non-resolving inflammatory response to accumulating A? peptide species is a cardinal feature in the development of Alzheimer's disease (AD). In response to accumulating A? peptide species, microglia, the innate immune cells of the brain, generate a toxic inflammatory response that a...
ORGANISM(S): Mus musculus 
2014-04-25 | E-GEOD-55627 | biostudies-arrayexpress
TranscriptomicsIn vivo response of microglia to Aβ and prostaglandin-E2 EP2 receptor signaling
Microglia, the innate immune cells of the central nervous system, perform critical inflammatory and non-inflammatory functions to maintain homeostasis and normal neural function. However in Alzheimer’s disease (AD), these beneficial functions become progressively impaired, contributing to synapse a...
ORGANISM(S): Mus musculus 
2015-02-20 | E-GEOD-57181 | biostudies-arrayexpress
TranscriptomicsEffect of ibuprofen on hippocampal gene expression in APP-PS1 mice
NSAIDs (non-steroidal anti-inflammatory drugs) inhibit cyclooxygenase (COX) enzymes and prevent Alzheimer'™s disease (AD) at preclinical stages in cognitively normal aging populations. We modeled NSAID prevention of memory impairment in AD model mice to identify novel targets of NSAID action. We fou...
ORGANISM(S): Mus musculus 
2016-06-14 | E-GEOD-67306 | biostudies-arrayexpress
Sort   by:  
 Page size