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TranscriptomicsTranscription profiling of mouse embyronic fibroblasts from wild type and E2F2 null mice to generate a signature for E2F2 pathway activation
We have used primary MEFs derived from wild type and E2F4 null mice growing asynchrounously in serum to generate a signature for E2F4 pathway activation. 10 wild type and 10 E2F4 null samples were each assayed using the Affymetrics Mouse Genome 430A 2.0 array. Experiment Overall Design: MEFs from 3...
ORGANISM(S): Mus musculus 
2008-10-24 | E-GEOD-11039 | biostudies-arrayexpress
TranscriptomicsMMTV-Myc tumor development in E2F-null backgrounds
Advances in genomic signatures have begun to dissect breast cancer heterogeneity, and application of these signatures will allow the prediction of which pathways are important in tumor development. Here we used genomic signatures to predict involvement of specific E2F transcription factors in Myc-i...
ORGANISM(S): Mus musculus 
2011-12-29 | E-GEOD-24594 | biostudies-arrayexpress
TranscriptomicsExpression data from low expressing T58A Mutant Myc Induced Tumors
We used microarrays to futher characterize the effects of T58A mutation in Myc on mammary tumorigenesis. 17 MMTV-Myc T58A mammary tumors were used for RNA extraction and hybridization on Affymetrix microarrays.
ORGANISM(S): Mus musculus 
2012-07-08 | E-GEOD-30805 | biostudies-arrayexpress
TranscriptomicsIncreased metastasis with loss of E2F2 in Myc-driven tumors
In human breast cancer, mortality is associated with metastasis to distant sites. Therefore, it is critical to elucidate the biological mechanisms that underlie tumor progression and metastasis. Using signaling pathway signatures we previously predicted a role for E2F transcription factors in Myc i...
ORGANISM(S): Mus musculus 
2016-08-08 | E-GEOD-71815 | biostudies-arrayexpress
TranscriptomicsGenetic Heterogeneity in Mouse Mammary Tumors
Human cancers result from a complex series of genetic alterations resulting in heterogeneous disease states. Dissecting this heterogeneity is critical for understanding underlying mechanisms and providing opportunities for therapeutics matching the complexity. Mouse models of cancer have generally b...
ORGANISM(S): Mus musculus 
2010-03-03 | E-GEOD-15904 | biostudies-arrayexpress
MetabolomicsTargeted metabolomic analysis in hepatic extracts, serum, and urine of female mice gavaged with TCDD every 4 days for 28 days
TCDD is an environmental contaminant that elicits a number of hepatic effects including fat accumulation, inflammation, and fibrosis that can progress to hepatocellular carcinoma. RNA-Seq and targeted metabolomics were integrated with complementary dioxin response element (DRE) location and aryl hyd...
2017-02-02 | MTBLS225 | MetaboLights
UnknownTip30 controls differentiation of murine mammary luminal progenitor to estrogen receptor-positive luminal cell through regulating FoxA1 expression.
Not available
S-EPMC4047867 | biostudies-literature
UnknownLPA receptor activity is basal specific and coincident with early pregnancy and involution during mammary gland postnatal development.
Not available
S-EPMC5093903 | biostudies-literature
UnknownInsight into mammary gland development and tumor progression in an E2F5 conditional knockout mouse model.
Not available
S-EPMC11554565 | biostudies-literature
UnknownIntegrated analyses of murine breast cancer models reveal critical parallels with human disease.
Not available
S-EPMC6646342 | biostudies-literature
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