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ProteomicsDefining the Tumor Microenvironment by Integration of Im-munohistochemistry and Extracellular Matrix Targeted Imaging Mass Spectrometry
Breast stroma plays a significant role in breast cancer risk and progression yet remains poorly understood. In breast stroma, collagen is the most abundantly expressed protein and its increased deposition and alignment contributes to progression and poor prognosis. Collagen post-translation modifica...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD028107 | Pride
Imaging mass spectrometry (ims)  immunohistochemistry (ihc)  pten  stroma  ecm  tumor microenvironment  breast cancer 
ProteomicsCollagen Fiber Regulation in Human Pediatric Aortic Valve Development and Disease
Congenital aortic valve stenosis (CAVS) affects up to 10% of the world population without medical therapies to treat the disease. New molecular targets are continually being sought that can halt CAVS progression. Collagen deregulation is a hallmark of CAVS yet remains mostly undefined. Here, histol...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD021990 | Pride
Collagen Aortic valve stenosis 
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