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The terminal stage of the complement activation pathways, the membrane attack complex (MAC), is upregulated in diabetic and rheumatoid arthritis patients, contributing pathologically by increasing inflammation. Previous research has highlighted that a sublytic dose of MAC can initiate NLRP3 inflamma...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD027316 | Pride
Here we present a strategy for the identification and quantitation of histone methylation that utilizes nondeuterated acetic anhydride to fully acetylate all free lysine residues prior to digestion with trypsin and analysis by LC-MS/MS.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
Mass spectrometry was used to determine IQGAP1 is a substrate of MET and c-Src, and is phosphorylated exclusively on Tyr-1510 under conditions with enhanced MET or c-Src cellular activity.
ORGANISM(S): Human 
Mass spectrometry was used to determine that cellular IQGAP1 and IQGAP2 proteins are phosphorylated at multiple tyrosine residues upon sodium orthovanadate treatment.
ORGANISM(S): Human 
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