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UnknownMetabolic pathways regulated by TAp73 in response to oxidative stress.
Reactive oxygen species are involved in both physiological and pathological processes including neurodegeneration and cancer. Therefore, cells have developed scavenging mechanisms to maintain redox homeostasis under control. Tumor suppressor genes play a critical role in the regulation of antioxidan...
S-EPMC5058650 | biostudies-literature
UnknownIntegrin-β4 is a novel transcriptional target of TAp73.
As a member of p53 family, p73 has attracted intense investigations due to its structural and functional similarities to p53. Among more than ten p73 variants, the transactivation (TA) domain-containing isoform TAp73 is the one that imitates the p53's behavior most. TAp73 induces apoptosis and cell ...
S-EPMC5969564 | biostudies-literature
UnknownSetdb1, a novel interactor of ΔNp63, is involved in breast tumorigenesis.
ΔNp63 has been recently involved in self-renewal potential of breast cancer stem cells. Although the p63 transcriptional profile has been extensively characterized, our knowledge of the p63-binding partners potentially involved in the regulation of breast tumour progression is limited. Here, we perf...
S-EPMC5045360 | biostudies-literature
UnknownTwo new p73 splice variants, gamma and delta, with different transcriptional activity.
p73 has been recently identified as a new structural and functional homologue of the transcription factor p53. It is expressed in either a full-length form, alpha, or a shorter beta mRNA variant, with exon 13 spliced out. Here we report the identification and functional characterization of two new p...
S-EPMC2212516 | biostudies-literature
UnknownZNF185 is a p53 target gene following DNA damage.
The transcription factor p53 is a key player in the tumour suppressive DNA damage response and a growing number of target genes involved in these pathways has been identified. p53 has been shown to be implicated in controlling cell motility and its mutant form enhances metastasis by loss of cell dir...
S-EPMC6286825 | biostudies-literature
UnknownTAp63 regulates bone remodeling by modulating the expression of TNFRSF11B/Osteoprotegerin.

Abbreviations

MSC, mesenchymal stem cells; OPG, osteoprotegerin; RUNX2, Run-trelated transcription factor 2.
S-EPMC8794505 | biostudies-literature
UnknownZNF185 is a p63 target gene critical for epidermal differentiation and squamous cell carcinoma development.
Development and maintenance of healthy stratified epithelia require the coordination of complex transcriptional programmes. The transcription factor p63, a member of the p53 family, plays a crucial role in epithelial development and homeostasis. Analysis of the p63-dependent transcriptome indicated ...
S-EPMC6755960 | biostudies-literature
UnknownGLS2 is transcriptionally regulated by p73 and contributes to neuronal differentiation.
Not available
S-EPMC4615081 | biostudies-literature
UnknownImpact of Mediterranean diet on metabolic syndrome, cancer and longevity.
Obesity symbolizes a major public health problem. Overweight and obesity are associated to the occurrence of the metabolic syndrome and to adipose tissue dysfunction. The adipose tissue is metabolically active and an endocrine organ, whose dysregulation causes a low-grade inflammatory state and ecto...
S-EPMC5352455 | biostudies-literature
UnknownZNF281/Zfp281 is a target of miR-1 and counteracts muscle differentiation.
Defects in achieving a fully differentiated state and aberrant expression of genes and microRNAs (miRs) involved in differentiation are common to virtually all tumor types. Here, we demonstrate that the zinc finger transcription factor ZNF281/Zfp281 is down-regulated during epithelial, muscle, and g...
S-EPMC6998661 | biostudies-literature
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