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TranscriptomicsGene Expression Profiling Identifies Interferon Signalling Molecules and IGFBP3 in Human Degenerative Annulus Fibrosus
Low back pain is a major cause of disability especially for people between 20 and 50 years of age. As a costly healthcare problem, it imposes a serious socio-economic burden. Current surgical therapies have considerable drawbacks and fail to replace the normal disc in facilitating spinal movements a...
ORGANISM(S): Homo sapiens 
2015-10-23 | E-GEOD-70362 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of bovine nucleus pulposus, carticular cartilage and annulus fibrosus cells to further determine expression in normal and degenerate human intervertebral disc
The aim of this transcription profiling study was to identify novel genes that could be used to distinguish bovine Nucleus pulposus (NP) cells from articular cartilage (AC) and annulus fibrosus (AF) cells and to further determine their expression in normal and degenerate human intervertebral disc (I...
ORGANISM(S): Bos taurus 
2010-03-05 | E-MEXP-2291 | biostudies-arrayexpress
TranscriptomicsGene Expression Data from Senescent vs Non-senescent Cells in the in Vivo Human Annulus
The presence of senescent cells in the aging/degenerating human disc is now well-recognized. Senescent cells are viable, cannot divide, remain metabolically active and accumulate within the disc over time. Molecular analysis of senescent cells in tissue, however, offers a special challenge since the...
ORGANISM(S): Homo sapiens 
2009-07-15 | E-GEOD-17077 | biostudies-arrayexpress
TranscriptomicsHuman annulus disc cells grown in a 3D collagen sponge and exposed to TNF-a
The objective of this study was to determine how TNF-a, an important proinflammatory cytokine, affects gene expression in the human annulus. Cells were grown in a 3D collagen construct for 14 days with TNF-a. mRNA was isolated and subjected to microarray. Fold changes in gene expression were determ...
ORGANISM(S): Homo sapiens 
2012-10-31 | E-GEOD-41883 | biostudies-arrayexpress
TranscriptomicsAn Organ Culture System to Model Early Degenerative Changes of the Intervertebral Disc: II Profiling Global Gene Expression Changes
To mimic a degenerative insult, rat intervertebral discs were cultured in the presence of TNF-alpha, IL-1beta and serum limiting conditions. Gene expression analysis was performed using a microarray to identify differential gene expression between experimental and control groups. The discs were coll...
ORGANISM(S): Rattus norvegicus 
2012-11-29 | E-GEOD-42611 | biostudies-arrayexpress
TranscriptomicsTGF-beta and BMP mediated gene expression in cultured sclerotome.
Very little is known about how intervertebral disc (IVD) is formed or maintained. Members of the TGF-beta superfamily are secreted signaling proteins that regulate many aspects of development including cellular differentiation. We recently showed that deletion of Tgfbr2 in Col2a expressing tissue re...
ORGANISM(S): Mus musculus 
2010-04-09 | E-GEOD-18648 | biostudies-arrayexpress
GenomicsShared and compartment-specific processes in nucleus pulposus and annulus fibrosus during intervertebral disc degeneration
Shared and compartment-specific processes in nucleus pulposus and annulus fibrosus during intervertebral disc degeneration
PRJNA962589 | ENA
UnknownTGF-β1-supplemented decellularized annulus fibrosus matrix hydrogels promote annulus fibrosus repair.
Not available
S-EPMC9108517 | biostudies-literature
TranscriptomicsGene Expression Profiling Identifies Interferon Signalling Molecules and IGFBP3 in Human Degenerative Annulus Fibrosus
Low back pain is a major cause of disability especially for people between 20 and 50 years of age. As a costly healthcare problem, it imposes a serious socio-economic burden. Current surgical therapies have considerable drawbacks and fail to replace the normal disc in facilitating spinal movements a...
ORGANISM(S): Homo sapiens 
2015-10-23 | GSE70362 | GEO
TranscriptomicsGene expression in embryonic intervertebral disc and vertebrae.
Very little is known about how intervertebral disc (IVD) is formed or maintained. Members of the TGF-ß superfamily are secreted signaling proteins that regulate many aspects of development including cellular differentiation. We recently showed that deletion of Tgfbr2 in Col2a expressing tissue resul...
ORGANISM(S): Mus musculus 
2010-04-09 | E-GEOD-18647 | biostudies-arrayexpress
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