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The unfolded protein response (UPR), induced by endoplasmic reticulum (ER) stress, regulates the expression of factors that restore protein folding homeostasis. However, in the liver and kidney, ER stress also leads to lipid accumulation, accompanied at least in the liver by transcriptional suppress...
2017-06-23 | MTBLS472 | MetaboLights
The anorexia mouse model, anx/anx, carries a spontaneous mutation not yet identified and homozygous mutants are characterized by anorexia-cachexia, growth failure and abnormal behavior, such as head weaving, hyperactivity, and ataxia. In order to test if miRNA machinery could influence the phenotyp...
ORGANISM(S): Mus musculus 
Using the Infinium Human DNA Methylation EPIC BeadChip array (850 K), we analyzed genome-wide DNA methylation patterns in peripheral blood leukocytes collected from 10 female patients with anorexia with primary (n= 4) or secondary (n= 6) amenorrhea and 13 healthy pubertal girls matched by age (E-MT...
ORGANISM(S): Homo sapiens 
The anx/anx mouse displays poor appetite and lean appearance and is considered a good model for the study of anorexia nervosa. To identify new genes involved in feeding behavior and body weight regulation we performed an expression profiling in the hypothalamus of the anx/anx mice. Using commercial ...
ORGANISM(S): Mus musculus 
As part of the Genetic Consortium for Anorexia Nervosa (GCAN) and Wellcome Trust Case Control Consortium 3 (WTCCC3), we have amassed the largest anorexia nervosa (AN) sample in the world (~4,000). Following the WTCCC3 GWAS, we secured funding from the Klarman Family Foundation to extend the genetic ...
Infection-induced anorexia and the gut microbiota
Anorexia Nervosa Genetics Initiative (ANGI)
Anorexia Nervosa Genetics Initiative (ANGI)
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