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ProteomicsDegron models: a toolbox for rapid in vivo depletion of essential proteins regulating mRNA metabolism
Due to their essentiality, studying proteins involved in fundamental processes in vivo is challenging. PROTAC-based systems offer time-controlled protein depletion, but their characterization in vivo remains limited. Here, with an efficient direct zygote editing protocol, we generated degron-tag mod...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-26 | PXD069282 | Pride
Tmt Degron-tag Liver Mouse 
ProteomicsDIS3L, cytoplasmic exosome catalytic subunit, is essential for development but not cell viability in mice.
Among numerous enzymes involved in RNA decay, processive exoribonucleases are the most prominent group responsible for the degradation of the entire RNA molecules. The role of mammalian cytoplasmic 3’-5’ exonuclease DIS3L at the organismal level remained unknown. Herein we established knock-in and k...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD038745 | Pride
Dis3l Rna 
ProteomicsCPTAC CCRCC Discovery Study - DIA Proteome
This is a supplementary study to the CPTAC CCRCC Discovery Study - Proteome. Unlabeled, digested peptide material from individual tissue samples (ccRCC and NAT) was spiked with index Retention Time (iRT) peptides (Biognosys) and subjected to data-independent acquisition (DIA) analysis. Kidney cance...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-10-04 | MSV000093041 | MassIVE
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