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ProteomicsDIS3L, cytoplasmic exosome catalytic subunit, is essential for development but not cell viability in mice.
Among numerous enzymes involved in RNA decay, processive exoribonucleases are the most prominent group responsible for the degradation of the entire RNA molecules. The role of mammalian cytoplasmic 3’-5’ exonuclease DIS3L at the organismal level remained unknown. Herein we established knock-in and k...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD038745 | Pride
Dis3l Rna 
TranscriptomicsmicroRNA-seq of miRNAs from control and DIS3L knockdown HeLa cells
DIS3L is a 3' to 5' exonuclease that plays a role in the degradation of cellular RNAs. The aim of this experiment was to identify miRNAs that are regulated by DIS3L in human cells.
ORGANISM(S): Homo sapiens 
2018-12-29 | E-MTAB-7548 | biostudies-arrayexpress
GenomicsmicroRNA-seq of miRNAs from control and DIS3L knockdown HeLa cells
microRNA-seq of miRNAs from control and DIS3L knockdown HeLa cells
PRJEB30474 | ENA
GenomicsDIS3L, cytoplasmic exosome catalytic subunit, is essential for development but not cell viability in mice.
DIS3L, cytoplasmic exosome catalytic subunit, is essential for development but not cell viability in mice.
PRJNA911571 | ENA
TranscriptomicsDIS3L, cytoplasmic exosome catalytic subunit, is essential for development but not cell viability in mice.  
Among numerous enzymes involved in RNA decay, processive exoribonucleases are the most prominent group responsible for the degradation of the entire RNA molecules. The role of mammalian cytoplasmic 3’-5’ exonuclease DIS3L at the organismal level remained unknown. Herein we established knock-in and k...
ORGANISM(S): Mus musculus 
2025-04-23 | GSE220800 | GEO
TranscriptomicsMYC induces oncogenic stress through RNA decay and ribonucleotide catabolism
To investigate the transcriptome that might be dysregulated by MYC hyperactivation specifically when DIS3L is downregulated.
ORGANISM(S): Homo sapiens 
2023-01-22 | GSE223046 | GEO
UnknownLandscape of functional interactions of human processive ribonucleases revealed by high-throughput siRNA screenings.
Not available
S-EPMC8437785 | biostudies-literature
UnknownPARN Modulates Y RNA Stability and Its 3'-End Formation.
Not available
S-EPMC5615183 | biostudies-literature
UnknownMeta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error.
Not available
S-EPMC4820539 | biostudies-literature
UnknownThe exoribonuclease Dis3L2 defines a novel eukaryotic RNA degradation pathway.
Not available
S-EPMC3981172 | biostudies-literature
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