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MetabolomicsQuantitative metabolomic analysis of changes in the lens and aqueous humor under development of age-related nuclear cataract

INTRODUCTION: Metabolites are essential for the proper functioning of the eye lens, they either enter the lens from the aqueous humor (AH), or are synthesized in the lens epithelium. Antioxidants, osmolytes and UV filters are especially important for the lens protection, and thei...

2022-11-07 | MTBLS740 | MetaboLights
TranscriptomicsDifferentiation state-specific mitochondrial dynamic regulatory networks are revealed by global transcriptional analysis of the developing chicken lens.
The mature eye lens contains a surface layer of epithelial cells called the lens epithelium that require a functional mitochondrial population to maintain the homeostasis and transparency of the entire lens. The lens epithelium overlies a core of terminally differentiated fiber cells that must degr...
ORGANISM(S): Gallus gallus 
2014-07-02 | E-GEOD-53976 | biostudies-arrayexpress
TranscriptomicsComparison of lens gene expression between the control and DicerCN mouse embryos at E13.5
In order to investigate the mechanism for the progressive lens degeneration caused by targeted deletion of Dicer, we compared expression profiles of protein-coding genes in wild type and DicerCN lenses at E13.5, at a time before gross morphological changes had occurred. We identified distinct class...
ORGANISM(S): Mus musculus 
2010-04-09 | E-GEOD-16209 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse LE-AP-2a mutants vs. wild-type P0 littermate lenses to investigate cell autonomous roles for AP-2alpha in lens vesicle separation and maintenance of the lens epithelial cell phenotype.
This is a comparative microarray analysis of LE-AP-2a mutants vs. wild-type P0 littermate lenses. This analysis revealed differential gene expression of 415 mRNAs, including reduced expression of genes important for maintaining lens epithelial cell phenotype, such as E-cadherin. Experiment Overall D...
ORGANISM(S): Mus musculus 
2009-01-31 | E-GEOD-14536 | biostudies-arrayexpress
TranscriptomicsIdentification of genes associated with lens regeneration from the cornea in Xenopus laevis tadpoles
Surgical removal of the lens from larval Xenopus laevis results in a rapid transdifferention of central corneal cells to form a new lens. The trigger for this process is understood to be an induction event arising from the unprecedented contact between the cornea and the vitreous humour that occurs ...
ORGANISM(S): Xenopus laevis 
2011-09-13 | E-GEOD-28014 | biostudies-arrayexpress
ProteomicsProteomic analysis of healthy human Aqueous Humour, Anterior Lens Capsules, and Crystalline Lenses
Participants were recruited from the Ophthalmology Department among patients scheduled for cataract surgery. Patients were stratified into four distinct groups based on their clinical profiles. ARC group (Age-Related Cataract) included individuals over the age of 75 without a history of diabetes; DC...
ORGANISM(S): Homo sapiens (Human) 
2025-12-01 | PXD069667 | Pride
Anterior lens Human aqueous humour Capsules Proteomics 
TranscriptomicsChromatin Remodeling Enzyme Smarca5/Snf2h Regulates Cell Cycle Exit, Differentiation of the Lens Epithelium, and Denucleation of Lens Fiber Cells
Genome-wide approach to identify the cell-autonomous role of Snf2h in lens fiber cell terminal differentiation. Differential gene expression was analyzed in Snf2h lens-conditional knockout and wildtype newborn mouse eyeballs, with subsequent comparison of this data with the Brg1 lens-conditional kno...
ORGANISM(S): Mus musculus 
2012-10-18 | E-GEOD-41608 | biostudies-arrayexpress
TranscriptomicsmiRNA microarray of human aqueous humor and lens capsule with glaucoma
A miRNA PCR array comprising 84 miRNAs was used to analyze the AH (glaucoma, n=3; control, n=3) and LC samples (glaucoma, n=3; control, n=4). Expression levels of 19 and 3 miRNAs were significantly upregulated in the AH and LC samples of the glaucoma group, respectively (p < 0.05).
ORGANISM(S): Homo sapiens 
2024-02-16 | E-MTAB-13771 | biostudies-arrayexpress
TranscriptomicsConditional ablation of the Notch2 receptor in the ocular lens
Notch signaling is essential for proper lens development, however the specific requirements of individual Notch receptors has not been previously investigated. Here we report the lens phenotypes of Notch2 conditionally mutant mice, which exhibited severe microphthalmia, reduced pupillary openings, d...
ORGANISM(S): Mus musculus 
2011-12-31 | E-GEOD-31643 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse SPARC-null vs. wild-type lens epithelium
SPARC is a matricellular glycoprotein involved in regulation of the extracellular matrix, growth factors, adhesion, and migration. SPARC-null mice have altered basement membranes and develop posterior sub-capsular cataracts with cell swelling and equatorial vacuoles. Exchange of fluid, nutrients, ...
ORGANISM(S): Mus musculus 
2009-05-11 | E-GEOD-13402 | biostudies-arrayexpress
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