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TranscriptomicsTranscription profiling of human HepG2 cell lines reveals hepatitis C virus core proten induces expression of genes regulating immune invasion and anti-apoptosis
Gene expression in HepG2 cell line
ORGANISM(S): Homo sapiens 
2007-10-02 | E-GEOD-2067 | biostudies-arrayexpress
GenomicsAnti-proliferative, Apoptosis and Anti-migration Properties on Androgen-independent Human Prostate Cancer by a Diarylpentanoid, MS13.
Anti-proliferative, Apoptosis and Anti-migration Properties on Androgen-independent Human Prostate Cancer by a Diarylpentanoid, MS13.
PRJNA743282 | ENA
GenomicsAn investigation of the effect of anti-apoptosis mutations on human pluripotent stem cells transcriptome when apoptosis stress was applied
An investigation of the effect of anti-apoptosis mutations on human pluripotent stem cells transcriptome when apoptosis stress was applied
PRJNA432033 | ENA
TranscriptomicsThe non-steroidal anti-inflammatory drugs Sulindac sulfide and Diclofenac induce apoptosis and differentiation in human acute myeloid leukemia cells through an AP-1 dependent pathway
Acute myeloid leukemia is a heterogeneous disease with regard to the underlying genetic and molecular pathophysiology. Non-steroidal anti-inflammatory drugs (NSAIDs) exert significant anti-proliferative effects in various malignant cells in vitro and in vivo. Hence, these agents can be utilized to s...
ORGANISM(S): Homo sapiens 
2011-03-26 | E-GEOD-28185 | biostudies-arrayexpress
TranscriptomicsRole of Apollon in human melanoma resistance to anti-tumor agents that activate the intrinsic or the extrinsic apoptosis pathways
PURPOSE: To assess the role of Apollon in melanoma resistance to intrinsic and extrinsic pathways of apoptosis and to identify strategies to reduce its expression. EXPERIMENTAL DESIGN: Expression of Apollon was assessed in melanoma cell lines and in surgical specimens.Gene expression profiling, m...
ORGANISM(S): Homo sapiens 
2012-07-10 | E-GEOD-34686 | biostudies-arrayexpress
GenomicsNovel MVA Vector Expressing Anti-apoptotic gene, B13R, Delays Apoptosis and Enhances Humoral Responses
Novel MVA Vector Expressing Anti-apoptotic gene, B13R, Delays Apoptosis and Enhances Humoral Responses
PRJNA490556 | ENA
ProteomicsRNF25-Mediated NF-κB Activation Drives Anti-Apoptosis and Therapy Resistance in Cancer
Dysregulation of the NF-κB pathway is frequently observed in cancers, where it contributes to therapy resistance by inhibiting apoptosis. Mass spectrometry (MS)-based proteomics were employed to identify factors associated with the anti-apoptotic process. We identify RNF25, an E3 ubiquitin ligase, a...
ORGANISM(S): Homo Sapiens 
2025-03-05 | PXD061521 |
TranscriptomicsStarvation and chemotherapy
Tumor chemoresistance is often associated to high aerobic glycolysis rates and reduced oxidative phosphorylation by cancer cells, a phenomenon called the “Warburg effect”. Thus, a treatment reversing the Warburg effect could decrease tumor cell survival both in the presence or absence of chemothera...
ORGANISM(S): Mus musculus 
2015-08-11 | E-GEOD-60653 | biostudies-arrayexpress
TranscriptomicsAnti-proliferative, Apoptosis and Anti-migration Properties on Androgen-independent Human Prostate Cancer by a Diarylpentanoid, MS13.
Diarylpentanoids exhibit a high degree of anti-cancer activity and stability in vitro over curcumin in prostate cancer cells. Hence, this study aims to investigate the effects of a diarylpentanoid, 1,5-bis(4-hydroxy-3-methoxyphenyl)-1,4-pentadiene-3-one (MS13) on cytotoxicity, anti-proliferative, ap...
ORGANISM(S): Homo sapiens 
2021-07-07 | GSE179324 | GEO
TranscriptomicsNuclear factor kappa B activation-induced anti-apoptosis renders HER2 positive cells drug resistant and accelerates tumor growth
Breast cancers with HER2 overexpression are sensitive to drugs targeting the receptor or its kinase activity. HER2-targeting drugs are initially effective against HER2- positive breast cancer, but resistance inevitably occurs. We previously found that nuclear factor kappa B is hyper-activated in the...
ORGANISM(S): Homo sapiens 
2014-02-13 | E-GEOD-52707 | biostudies-arrayexpress
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