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TranscriptomicsNon-steroidal Anti-inflammatory Drugs Decrease E2F1 Expression and Inhibit Cell Growth in Ovarian Cancer Cells
Epidemiological studies have shown that the regular use of non-steroidal anti-inflammatory (NSAIDs) drugs is associated with a reduced risk of various cancers. In addition, in vitro and experiments in mouse models have demonstrated that NSAIDs decrease tumor initiation and/or progression of several ...
ORGANISM(S): Homo sapiens 
2014-06-20 | E-GEOD-45052 | biostudies-arrayexpress
ProteomicsMulti-omics Study Reveals the Synergistic Anti-tumor Effects of Aspirin and Gemcitabine-based Chemotherapy on Pancreatic Cancer and the Underlying Mechanism
Pancreatic cancer is a highly malignant tumor that is well known for its poor prognosis. It has been reported that aspirin can reduce the risk of various cancers, but the potential role of aspirin and gemcitabine in pancreatic cancer pathogenesis and chemotherapy has not been studied. Therefore, we ...
ORGANISM(S): Homo sapiens (Human) 
2022-05-31 | PXD031910 | Pride
Pancreatic cancer Multi-omics Synergistic effect Aspirin Gemcitabine 
GenomicsResistance to anti-EGFR therapy in colorectal cancer
Monoclonal antibodies targeting the Epidermal Growth Factor Receptor (EGFR), such as cetuximab and panitumumab, have evolved to important therapeutic options in metastatic colorectal cancer (CRC). However, almost all patients with clinical response to anti-EGFR therapies show disease progression wit...
EGAS00001000582 | EGA
ProteomicsUnveiling the mechanism of action of nature-inspired anti-cancer compounds using a multi-Omics approach
MCF-7 breast cancer cells were treated with two novel anti-cancer compounds, SIMR_3058 and SIMR_3066, and the metabolome and proteome analysed by LC-MS/MS using a timsTOF.
ORGANISM(S): Homo sapiens (Human) 
2023-01-17 | PXD033257 | Pride
Anti-cancer Lc-msms Timstof Human Cells 
TranscriptomicsRedefining the Relevance of Established Cancer Cell Lines to the Study of Clinical Anti-Cancer Drug Resistance
Although in vitro models have been a cornerstone of anti-cancer drug development, their direct applicability to clinical cancer research has actually been uncertain. Using a state-of-the-art Taqman-based qRT-PCR assay, we investigated the multidrug resistance (MDR) transcriptome of six cancer types,...
ORGANISM(S): Homo sapiens 
2011-11-16 | E-GEOD-30034 | biostudies-arrayexpress
ProteomicsParacrine secretion of monounsaturated fatty acids prevents ferroptosis in triple negative breast cancer and reveals selenocysteine synthesis dependency for metastatic seeding.
The limited availability of therapeutic options for patients with triple-negative breast cancer (TNBC) contributes to the high rate of metastatic recurrence and poor prognosis. Ferroptosis is a cell death caused by iron-dependent lipid peroxidation counteracted by the antioxidant activity of selenop...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-05-17 | MSV000094784 | MassIVE
TranscriptomicsGene expression alterations in human colon cancer xenograft treated with anti-VEGF antibody
Recent randomized clinical trial revealed the additional effect of bevacizumab, a humanized monoclonal antibody against vascular endothelial growth factor (VEGF)-A, to conventional chemotherapy on survival of patients with metastatic colorectal cancer. However, a number of preclinical reports indica...
ORGANISM(S): Homo sapiens 
2013-05-25 | E-GEOD-47087 | biostudies-arrayexpress
GenomicsTumor sialylation controls effective anti-cancer immunity in breast cancer
Tumor sialylation controls effective anti-cancer immunity in breast cancer
PRJNA1314639 | ENA
GenomicsAnti-cancer activity of Cotyledon orbiculata extract
Anti-cancer activity of Cotyledon orbiculata extract
PRJNA657067 | ENA
ProteomicsA microbial supply chain for production of anti-cancer drug vinblastine
Monoterpene indole alkaloids (MIAs) are a diverse family of complex plant secondary metabolites with many medicinal properties, including the essential anti-cancer therapeutics vinblastine and vincristine. As MIAs are difficult to chemically synthesize, the world’s supply chain for vinblastine relie...
ORGANISM(S): Saccharomyces Cerevisiae 
2022-09-09 | PXD024976 | panorama
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