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ProteomicsClinical efficacy and biomarker analysis of stereotactic body radiotherapy combined with sintilimab and a bevacizumab biosimilar in anti-PD-1 refractory hepatocellular carcinoma
Immune checkpoint inhibitor (ICI) resistance in advanced hepatocellular carcinoma (HCC)poses a major therapeutic challenge. Here, we report a phase 2 trial evaluating stereotactic bodyradiotherapy (SBRT) combined with the anti-PD-1 antibody sintilimab and bevacizumabbiosimilar (lBI305) to re-sensiti...
ORGANISM(S): Homo sapiens (Human) 
2025-10-15 | PAD000004 | Pride
Sintilimab Bevacizumab biosimilar Anti-pd-1 refractory hepatocellular carcinoma Biomarkers of efficacy Stereotactic body radiotherapy 
ClinicalA Study of Combinations of D-CIK Immunotherapy And Anti-PD-1 In Refractory Solid Tumors
Background: Combinations of dendritic and cytokine-induced killer cell (D-CIK) based adoptive immunotherapy and anti-PD-1 antibody may enhance the immune response and stop cancer cells from growing. Objective: Phase II clinical trial to investigate the safety, clinical activity and toxicity of combi...
2223938 | ecrin-mdr-crc
UnknownDual TIGIT and PD-1 blockade with domvanalimab plus zimberelimab in hepatocellular carcinoma refractory to anti-PD-1 therapies: the phase 2 LIVERTI trial.
Not available
S-EPMC12219336 | biostudies-literature
UnknownEfficacy and safety of durvalumab rechallenge in advanced hepatocellular carcinoma patients refractory to prior anti-PD-1 therapy.
Not available
S-EPMC11632046 | biostudies-literature
UnknownStereotactic body radiotherapy with sintilimab and bevacizumab biosimilar in anti-PD-1 refractory hepatocellular carcinoma: the ReUNION-1 phase 2 trial.
Not available
S-EPMC12823611 | biostudies-literature
UnknownCharacterizing responsive and refractory orthotopic mouse models of hepatocellular carcinoma in cancer immunotherapy.
Not available
S-EPMC6619768 | biostudies-literature
UnknownValence-Change MnO2-Coated Arsenene Nanosheets as a Pin1 Inhibitor for Hepatocellular Carcinoma Treatment.
Not available
S-EPMC11311233 | biostudies-literature
UnknownRadiation improves antitumor effect of immune checkpoint inhibitor in murine hepatocellular carcinoma model.
Not available
S-EPMC5522235 | biostudies-literature
UnknownDevelopment and Validation of a Contrast-Enhanced CT-Based Radiomics Nomogram for Prediction of Therapeutic Efficacy of Anti-PD-1 Antibodies in Advanced HCC Patients.
Not available
S-EPMC7820863 | biostudies-literature
UnknownProlonged tumor response associated with sequential immune checkpoint inhibitor combination treatment and regorafenib in a patient with advanced pretreated hepatocellular carcinoma.
Not available
S-EPMC6465505 | biostudies-literature
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