Sort   by:  
 Page size 
MetabolomicsOmics and Computational Chemistry Reveal Environmental Residues of Anti-COVID-19 Drug Chloroquine Phosphate Drive Antibiotic Resistance Gene Dissemination
The widespread use of chloroquine phosphate (CQP) during the COVID-19 pandemic has led to its persistent residues in aquatic environments, yet its impact on the horizontal transfer of antibiotic resistance genes (ARGs) remains unknown. Herein, the effects and molecular mechanisms of CQP on plasmid-m...
2026-10-10 | MTBLS15990 | MetaboLights
MetabolomicsSystematic analyses of lipid mobilization by human lipid transfer proteins

Lipid transfer proteins (LTPs) maintain the specialised lipid compositions of biological membranes, and many are associated with disease. In eukaryotes, they support organellar functions by transporting lipids between compartmentalised metabolic pathways. However, for the majority of the hundreds...

2025-11-14 | MTBLS9567 | MetaboLights
MetabolomicsCell Membrane Remodeling Mediates Polymyxin B Resistance in Klebsiella pneumoniae: An Integrated Proteomics and Metabolomics Study
Polymyxin B (PB) is introduced into the clinic as the last-line therapy against carbapenem-resistant Klebsiella pneumoniae (CRKP). Unfortunately, increased resistance to PB in Klebsiella pneumoniae (K. pneumoniae) has threatened global health. Resistance of K. pneumoniae ...
2022-03-04 | MTBLS4132 | MetaboLights
ProteomicsMechanisms of antibiotic resistance to enrofloxacin in uropathogenic Escherichia coli in dog
Escherichia coli (E. coli) urinary tract infections (UTIs) are becoming a serious problem both for pets and humans (zoonosis) due to the close contact and to the increasing resistance to antibiotics. Great progress has been made in the discovery of novel antibiotics to counteract E. coli pathogens. ...
ORGANISM(S): Escherichia coli 
2015-06-05 | PXD002000 | Pride
Escherichia coli Enrofloxacin Antibiotic resistance Urinary tract infections 
MetabolomicsCommon Metabolic Pathways Implicated in Resistance to Chemotherapy Point to a Key Mitochondrial Role in Breast Cancer
Cancer cells are known to reprogram their metabolism to adapt to adverse conditions dictated by tumor growth and microenvironment. A subtype of cancer cells with stem-like properties, known as cancer stem cells (CSC), is thought to be responsible for tumor recurrence. In this study, we demonstrated ...
2019-08-19 | MTBLS678 | MetaboLights
MetabolomicsDecipher aging related skin microbiome and metabolites crosstalk from a chronologically matched cohort

Aging has shown close link to shifts in the skin microbiome in population cohort study. However, how variations in microbial communities relate to divergent skin aging within individuals of the same chronological ages remains unclear. In this study, we performed phenotypic, metabolomic and metage...

2025-01-03 | MTBLS11994 | MetaboLights
ProteomicsGenome- and proteome-wide analysis of lysine acetylation in Vibrio vulnificus Vv180806 reveals its regulatory roles in virulence and antibiotic resistance
V. vulnificus is an emergent pathogen and causes deadly septicemia in human. Protein acetylation regulates many important biological processes in bacteria. In this study, we identified the first lysine acetylome of V. vulnificus based on the whole-genome sequence of a cefoxitin-resistant strain isol...
ORGANISM(S): Vibrio vulnificus VV 
2020-12-01 | PXD020376 | Pride
Vibrio vulnificus  whole genome sequencing  acetylome  virulence  antibiotic resistance 
MetabolomicsHfq Regulates Efflux Pump Expression and Purine Metabolic Pathway to Increase the Trimethoprim Resistance in Aeromonas veronii

Aeromonas veronii (A. veronii) is a zoonotic pathogen. It causes clinically a variety of diseases such as dysentery, bacteremia, and meningitis. And it also brings huge losses to aquaculture. A. veronii has been documented as a multiple antibiotic resistant bacterium. Hfq (host factor for RNA bac...

2020-02-19 | MTBLS1411 | MetaboLights
ProteomicsAcetyl-proteome profiling of Staphylococcus aureus revealed lysine acetylation in bacterial antibiotic resistance
Protein post-translational modifications (PTMs) play crucial roles in various biological processes across prokaryotes and eukaryotes. Lysine acetylation (Kac), which is observed in different bacteria species and is known to be a dynamic and reversible PTM involved in numerous physiological functions...
ORGANISM(S): Staphylococcus aureus 
2024-10-17 | PXD043277 | Pride
Post-translational modification  staphylococcus aureus  antibiotic resistance  lysine acetylation  ribosome 
ProteomicsA Peptidomimetic Antibiotic Interacts with the Periplasmic Domain of LptD from Pseudomonas aeruginosa
Gram-negative bacterial infections are causing increasing levels of morbidity due to the rise of resistance to established antibiotics. New antibiotic classes with distinct molecular mode of action are therefore required. Recently, a family of macrocyclic peptidomimetics was discovered that target t...
ORGANISM(S): Pseudomonas Aeruginosa Pao1 (ncbitaxon:208964) 
2020-02-04 | MSV000084898 | MassIVE
Sort   by:  
 Page size