Anticancer agents

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Unknown (5512)
Transcriptomics (236)
Genomics (161)
Proteomics (78)
Metabolomics (14)
Clinical (8)
Other (5)
Genomic (2)
Multiomics (2)
Methylation profiling (1)

Organisms

Homo sapiens (219)
Aerococcus urinae NBRC 15544 = CCUG 36881 (49)
Allexis (49)
Canis lupus familiaris (49)
Carya cathayensis (49)
Clostridioides difficile 630 (49)
Cyanophora paradoxa (49)
Ensifer adhaerens (49)
Enterococcus faecalis (49)
Globicatella sanguinis (49)
Histomonas meleagridis (49)
Human immunodeficiency virus 1 (49)
Listeria monocytogenes (49)
Lotus japonicus (49)
Mus musculus (32)
Rattus norvegicus (7)
Saccharomyces cerevisiae (5)
Escherichia coli (2)
Danio rerio (2)
Dictyostelium discoideum AX4 (2)
Canis lupus familiaris (2)
Phaeobacter inhibens (1)
Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 (1)
Schizosaccharomyces pombe (1)
Staphylococcus aureus (1)
Candida albicans (1)
Arabidopsis thaliana (1)
Cryptococcus neoformans (1)
Eunicea asperula (1)
cellular organisms (1)

Organisms

Homo sapiens (103)
Mus musculus (7)
Rattus norvegicus (4)
Dictyostelium discoideum AX4 (1)
Rhazya stricta (1)
Streptomyces peucetius subsp. caesius ATCC 27952 (1)
Actinomycetes (1)
Cryptococcus neoformans (1)
Canis lupus familiaris (1)
human gut metagenome (1)
Saccharomyces cerevisiae (1)

Repository

ENA (145)
biostudies-arrayexpress (134)
geo (118)
pride (49)
MassIVE (14)
MetaboLights (11)
jPOST (10)
EGA (6)
iProX (5)
GNPS (3)
dbGaP (2)

Tissue

HCT-116 cell (19)
Colon (18)
Cell culture (13)
Epithelial cell (8)
Permanent cell line cell (3)
Bone marrow (2)
Leukocyte (2)
Melanocyte (2)
Whole body (2)
Blood (1)
Blood cell (1)
Breast (1)
Breast cancer cell line (1)
Cell suspension culture (1)
Liver (1)
Lung (1)
Macrophage (1)
Monocyte (1)
Retinal pigment epithelial cell (1)
Venom (1)

Disease

Breast cancer (5)
Colon cancer (4)
Colorectal Neoplasms (3)
Acute leukemia (2)
Malignant neoplasm of ovary (2)
Primary acute lymphoblastic leukemia (1)
Small cell cancer (1)
Fibrosarcoma (1)
Acute lymphoblastic leukemia (1)
Leukemia (1)
Glioblastoma (1)
Multiple myeloma (1)
Hodgkins lymphoma (1)
Colorectal cancer liver metastases (CRLM) (1)
Hypersensitivity (1)
Carcinoma, Hepatocellular (1)
Endometrial Neoplasms (1)
Carcinoma (1)
Brain cancer (1)
Colorectal carcinoma (1)
Liver cancer (1)
Melanoma (1)

Technology Type

Mass Spectrometry (49)
Shotgun proteomics (35)
Mass spectrometry (7)
Bottom-up proteomics (7)
Data-dependent acquisition (6)
Mass spectrometry assay (3)
Affinity purification coupled with mass spectrometry proteomics (2)
HDMSE (2)
HiSeq X Ten, ILLUMINA, Illumina HiSeq 2500 (1)
Illumina HiSeq 2500, ILLUMINA (1)
NMR spectroscopy (1)
Chemical cross-linking coupled with mass spectrometry proteomics (1)
Data-independent acquisition (1)
Gel-based experiment (1)
MSE (1)

Instrument Platform

Q Exactive (6)
Illumina HiSeq 2000 (2)
NextSeq 500 (2)
ACQUITY RDa Detector (2)
LCMS-9030 (2)
Orbitrap Fusion Lumos (2)
Liquid Chromatography MS - positive - reverse-phase (2)
Liquid Chromatography MS - negative - reverse-phase (2)
Liquid Chromatography MS - positive - reverse phase (2)
Liquid Chromatography MS - negative - reverse phase (2)
Element AVITI (1)
ScanArray Express HT [PerkinElmer] (1)
Illumina NovaSeq 6000 (1)
6540 Q-TOF LC/MS|1002789 (1)
Orbitrap Exploris 240 (1)
LTQ Orbitrap (1)
LTQ Orbitrap Velos Pro (1)
Orbitrap Eclipse (1)
Orbitrap Exploris 480 (1)
Orbitrap Fusion (1)
Q Exactive Plus (1)
TripleTOF 6600 (1)
Gas Chromatography MS - (1)
Gas Chromatography MS - Positive (GC-MS (Positive)) (1)
Liquid Chromatography MS - Positive (LC-MS (Positive)) (1)
Gas Chromatography MS - positive (1)
Bruker (1)
Liquid Chromatography MS - alternating - hilic (1)
Liquid Chromatography MS - alternating - reverse phase (1)
Liquid Chromatography MS - negative - hilic (1)

Publication Date

2022 (34)
2010 (30)
2018 (28)
2025 (24)
2026 (22)
2013 (21)
2011 (20)
2023 (19)
2008 (18)
2024 (17)
2016 (16)
2012 (15)
2021 (14)
2015 (13)
2014 (11)
2020 (10)
2007 (9)
2009 (7)
2017 (6)
2019 (4)
2006 (2)
2004 (1)

CHEBI ID

CHEBI:25017 (3)
CHEBI:15428 (3)
CHEBI:27266 (3)
CHEBI:32816 (3)
CHEBI:28744 (2)
CHEBI:24400 (2)
CHEBI:73989 (2)
CHEBI:1189 (2)
CHEBI:28955 (2)
CHEBI:81556 (2)
CHEBI:27974 (2)
CHEBI:34778 (2)
CHEBI:3908 (2)
CHEBI:17992 (2)
CHEBI:17263 (2)
CHEBI:18307 (2)
CHEBI:81555 (2)
CHEBI:10106 (2)
CHEBI:34741 (2)
CHEBI:18132 (2)
CHEBI:26986 (2)
CHEBI:17724 (2)
CHEBI:24898 (2)
CHEBI:28842 (2)
CHEBI:6650 (2)
CHEBI:28197 (2)
CHEBI:28044 (2)
CHEBI:16335 (2)
CHEBI:16010 (2)
CHEBI:18183 (2)

Metabolite Name

Choline (4)
Glycine (3)
Glycitein (3)
L-Lysine (3)
5-Hydroxyindoleacetic acid (3)
Adenosine (3)
Alanine (3)
Creatinine (3)
L-Carnitine (3)
DHOAA(AcO)-Val-Phe(NMe)-Pro-Phe(NMe)-Gly-OMe (2)
Calcium carbonate (2)
Benzobicyclon (2)
Malyngamide K (2)
Cyclotricuspidoside C (2)
Spheroidenone (2)
Malyngamide T (2)
Oxalyl-CoA (2)
24-Methylcycloart-23-en-3beta-yl acetate (2)
10-Deacetylbaccatin III (2)
3-Buten-1-amine (2)
Spirilloxanthin (2)
Imperialine (2)
Hypaconitine (2)
2'',3'',6''-Trigalloyliriflophenone 3-C-glucoside (2)
(3b,20R,22R)-3,20,27-Trihydroxy-1-oxowitha-5,24-dienolide 3-glucoside (2)
Endomorphin-1 (2)
Atorvastatin (2)
1,1'-[1,12-Dodecanediylbis(oxy)]bisbenzene (2)
Ranitidine (2)
Mycinamicin III (2)

First Public Date

2014 (23)
2018 (22)
2024 (20)
2026 (18)
2025 (14)
2022 (12)
2023 (11)
2021 (6)
2019 (4)
2017 (4)
2015 (4)
2013 (3)
2020 (2)
2016 (2)

Classification

fungi (1)
protozoa (1)

Study status

Recruiting (5)
Active, not recruiting (1)
Not yet recruiting (1)
Not provided (1)

Study type

Transcription profiling by array (105)
RNA-seq of coding RNA (10)
Interventional (7)
Unknown experiment type (5)
Genotyping by array (3)
Comparative genomic hybridization by array (3)
RNAi profiling by array (2)
Cell line - High-throughput sequencing (1)
ChIP-chip by array (1)
Other (1)
ChIP-seq (1)
Methylation profiling by array (1)
RNA-seq of coding RNA from single cells (1)
Observational patient registry (1)

Release Date

2022 (690)
2023 (592)
2025 (590)
2021 (559)
2024 (456)
2020 (455)
2019 (347)
2018 (303)
2017 (253)
2016 (231)
2014 (202)
2015 (191)
2013 (154)
2012 (140)
2011 (121)
2010 (92)
2026 (73)
2009 (65)
2008 (54)
2007 (28)
2005 (17)
2006 (15)
2004 (8)
2003 (4)
2000 (2)
1998 (2)
2001 (1)
1999 (1)

Lab affiliation

University of Vienna, Faculty of Chemistry, Department of Analytical Chemistry (16)
University of Vienna, Faculty of Chemistry, Department of Analytical Chemistry ( lab head ) (2)
Biology Department, Maynooth University (1)
CNIO (1)
Center for Cancer Research, Massachusetts General Hospital, Boston MA, USA;Department of Chemistry and Chemical Biology, Harvard University, Cambridge MA, USA. (1)
Centre for Genomic Regulation (1)
Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London (1)
Departamento de Bioquímica, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, 04023-901, Brazil; Laboratório Especial de Toxinologia Aplicada, Center of Toxins, Immune-Response and Cell Signaling, Instituto Butantan, São Paulo, 05503-900, Brazil (1)
Department of Analytical Chemistry, Faculty of Chemistry, University of Vienna, Waehringer Str. 38, 1090 Vienna (Austria) (1)
Department of Analytical Chemistry, University of Vienna, Austria (1)
Department of Biochemistry & Biotechnology, University of Thessaly, Biopolis, 41500, Larissa, Greece (1)
Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore, 117543 (1)
Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II (1)
Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research (NIPER), Hajipur, 844102, Bihar, India (1)
Department of Pharmacy, University of Salerno, 84084 Fisciano, Italy (1)
Department of Urology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA (1)
Genomic Instability Group, Spanish National Cancer Research Center (CNIO) (1)
Institute of Biology, Leiden University, Sylviusweg 72, 2333 BE Leiden, The Netherlands (1)
Institute of Oceanology, Chinese Academy of Sciences (1)
Laboratoire PRISM Universite de Lille (1)
Massachusetts Institute of Technology (1)
Max-Planck Institute of Biophysics (1)
Medical Malacology, Theodore Bilharz Research Institute, Giza, Egypt (1)
Medical Mycology Lab Biology Department Maynooth University Ireland (1)
NICM, Western Sydney University Faculty of pharmacy Cairo University (1)
No. 72 Binhai Road, Qingdao, Shandong Province, 266237, P.R. China (1)
Professor of Chemistry Duke University, Department of Chemistry (1)
Protein Analysis Facility, Center for Integrative Genomics, University of Lausanne (1)
Proteomics Unit, Department of Biochemistry, Institute of Chemistry, Federal University of Rio de Janeiro, Rio de Janeiro, 21941-909 Rio de Janeiro, RJ, Brazil; Laboratory of Proteomics, LADETEC, Institute of Chemistry, Federal University of Rio de Janeiro, Rio de Janeiro, 21941-598 Rio de Janeiro, RJ, Brazi (1)
State Key Laboratory of Synthetic Chemistry and Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, China (1)

Location

United States (3)
South Korea (2)
Spain (2)
United Kingdom (2)
Hong Kong (1)
Saudi Arabia (1)
Taiwan (1)
Turkey (1)
China (1)
Poland (1)
Germany (1)
Italy (1)
Canada (1)
Switzerland (1)
Japan (1)
France (1)

Keyword

Cetuximab (1)
Advanced gastrointestinal stromal tumors (1)
Ripretinib (1)
DCC-3116 (1)
Circulating cell free DNA (1)
AZD5305 (1)
Datopotamab deruxtecan (1)
Flourouracil (5-FU) (1)
TROPION-PanTumor03 (1)
Datopotamab Deruxtecan (Dato-DXd) (1)
Solid Tumours (1)
Antibody-drug conjugate (ADC) (1)
Trophoblast cell surface protein 2 (TROP2) (1)
Encorafenib (1)
NGS (1)
Advanced colorectal cancer (1)
Prednisone (1)
Doxorubicin (1)
Liposomal doxorubicin (1)
Carboplatin (1)
Gastrointestinal stromal tumors (1)
Fluorouracil (1)
Methylprednisolone (1)
Methylprednisolone Acetate (1)
Methylprednisolone Hemisuccinate (1)
Prednisolone (1)
Prednisolone acetate (1)
Prednisolone hemisuccinate (1)
Prednisolone phosphate (1)
Durvalumab (1)

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Microbiome Metabolism of Dietary Phytochemicals Controls the Anticancer Activity of PI3K Inhibitors

Phosphatidylinositol 3-kinase (PI3K) signaling is both the effector pathway of insulin and among the most frequently activated pathways in human cancer. In murine cancer models, the efficacy of PI3K inhibitors is dramatically enhanced by a ketogenic diet, with a proposed mechanism involving dietary ...

2025-03-26 | MTBLS10944 | MetaboLights

DNA-targeted platinum-acridine anticancer agents

Yeast homozygous and essential heterozygous deletion mutants were screened against novel platinum-containing compounds

ORGANISM(S): Schizosaccharomyces pombe

2012-08-28 | E-MTAB-1267 | biostudies-arrayexpress

Streptomyces peucetius subsp. caesius ATCC 27952

Produces anticancer agents

PRJNA13658 | ENA

Symmetric Bis-benzimidazoles Are Potent Anti-Staphylococcal Agents with Dual Inhibitory Mechanisms against DNA Gyrase

Various bis-benzimidazole derivatives have been reported to possess activity against Gram-positive pathogens. No mechanism of action has been elucidated to fully account for the antibacterial activity of this class of compounds. A group of symmetric bis-benzimidazoles (BBZ) designed as anticancer ag...

ORGANISM(S): Staphylococcus aureus

2012-10-14 | E-BUGS-106 | biostudies-arrayexpress

Sanguinarine, putative anticancer therapeutic, interacts,modulates and transcripts in the context of chromatin

DNA binding anticancer agents cause alteration in chromatin structure and dynamics. Here, we report the dynamic interaction of the DNA intercalator and potential anticancer, plant alkaloid, Sanguinarine (SGR) with chromatin. Association of SGR with different levels of chromatin structure was found t...

ORGANISM(S): Homo sapiens

2010-05-22 | E-GEOD-14314 | biostudies-arrayexpress

Theranostic Lysosomal Targeting Anticancer and Antimetastatic Agents: Half-Sandwich Iridium(III) Rhodamine Complexes.

Not available

S-EPMC6751730 | biostudies-literature

Differential gene expression for A2780 human ovarian cancer cells when exposed to a new osmium-based anticancer agent

Platinum-based metallodrugs are the most widely used anticancer agents. Their reduced effectiveness after repeat dosing (resistance) constitutes a major clinical problem. In this experiment we study a potent organo-osmium compound with improved activity over cisplatin and no cross-resistance in plat...

ORGANISM(S): Homo sapiens

2016-05-22 | E-MTAB-2758 | biostudies-arrayexpress

Sanguinarine, putative anticancer therapeutic, interacts, modulates and transcripts in the context of chromatin

DNA-binding anticancer agents cause alteration in chromatin structure and dynamics. Here, we report the dynamic interaction of the DNA intercalator and potential anticancer, plant alkaloid, sanguinarine (SGR) with chromatin. Association of SGR with different levels of chromatin structure was found t...

ORGANISM(S): Homo sapiens

2011-09-11 | E-GEOD-14777 | biostudies-arrayexpress

Drug-induced change in gene expression across NCI-60 cell lines after exposure to 15 anticancer agents for 2, 6 and 24h (cisplatin)

PRJNA478582 | ENA

Drug-induced change in gene expression across NCI-60 cell lines after exposure to 15 anticancer agents for 2, 6 and 24h (bortezomib)

PRJNA478577 | ENA

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