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MetabolomicsMetabolite assay of T cells that are antigen-specially activated by viscoelastic synthetic antigen presenting cells

Adoptive T cell receptor (TCR)–based immunotherapy offers a powerful strategy to target solid tumors. However, the physical properties of the antigen-presenting interface regulate T cell metabolic programming remains poorly defined. Here we develop synthetic viscoelastic activating cells (SynVAC)...

2026-09-03 | MTBLS15444 | MetaboLights
MetabolomicsDeep longitudinal multi-omics analysis of Bordetella pertussis cultivated in bioreactors highlights medium starvations and transitory metabolisms, associated to vaccine antigen biosynthesis variations and global virulence regulation

Bordetella pertussis is the bacterial causative agent of whooping cough, a serious respiratory illness. An extensive knowledge on its virulence regulation and metabolism is a key factor to ensure pertussis vaccine manufacturing process robustness. The aim of this study was to refine our ...

2023-02-21 | MTBLS5762 | MetaboLights
ProteomicsOptimizing High-Throughput Shotgun Immunoproteomics for Antigen Identification
Identification of individual proteins (i.e., antigens) which initiate and/or perpetuate adaptive immune responses has potential to greatly impact pre-clinical and clinical work across numerous fields. To date, however, the methodologies available to identify antigens responsible for driving adaptive...
ORGANISM(S): Bos taurus (Bovine) 
2023-04-18 | PXD038761 | Pride
Tandem-mass tag labeling Antigen identification Xenogeneic biomaterials Affinity chromatography Humoral immune response Proteomics 
MetabolomicsThe Leiden Longevity Study: Identification of biomarkers of the rate of ageing
The aim of the study is to identify genetic mechanisms of longevity and to characterize their interaction with the environment. Using the results the future health of people without familial longevity can be improved in old age. Long-lived siblings of European descent were recruited together with th...
2019-07-11 | MTBLS974 | MetaboLights
ModelsSontag2017 - Dynamic model of immune responses to antigen presentation by tumor or pathogen
This model of the immune system response to antigen presentation is based on the publication: Eduardo D.Sontag (2017) 'A Dynamic Model of Immune Responses to Antigen Presentation Predicts Different Regions of Tumor or Pathogen Elimination', Cell Systems, 4(2) DOI: 10.1016/j.cels.2016.12.003 Comment...
2024-09-02 | BIOMD0000001030 | BioModels
ProteomicsIdentification of novel target antigens in Membranous Nephorphathy
Membranous nephropathy (MN) is an autoimmune kidney disease with the clinical hallmark of causing high level proteinuria. MN is caused by circulating antibodies binding to targeting antigens on the surface of podocytes – specialized endothelial cells contributing to the formation of the glomerular...
ORGANISM(S): Homo sapiens (Human) 
2022-08-03 | PXD032713 | Pride
Human Glomerular disease 
TranscriptomicsActivity of the Bacillus anthracis 20 kDa protective antigen component
Edema factor of anthrax binds to the protective antigen (PA83) which cleaves to PA63 and PA20. The role of PA20 was examined using highthroughput gene expression analysis of human peripheral blood mononuclear cells (PBMC) exposed to PA20. Keywords: Toxicity determination PBMC obtained from differe...
ORGANISM(S): Homo sapiens 
2008-08-26 | E-GEOD-12533 | biostudies-arrayexpress
ProteomicsIP-to-MS: an unbiased workflow for antigen profiling
Immunoprecipitation is among the most widely utilized methods in biomedical research, with applications that include the identification of antibody targets and associated proteins. The path to identifying these targets is not straightforward, however, and often requires the use of chemical crosslink...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD056617 | Pride
Autoimmune disease Mass spectrometry Unbiased antigen identification Immunoprecipitation 
TranscriptomicsIntegrated SV40 T/t-antigen Cancer Signature in Aggressive Breast, Prostate and Lung Carcinomas with Poor Prognosis 2
Understanding the genetic architecture of cancer pathways that distinguishes subsets of human cancer is critical to developing new therapies that better target tumors based upon their molecular expression profiles. In this study, we identify an integrated gene signature from multiple transgenic mo...
ORGANISM(S): Mus musculus 
2007-09-01 | E-GEOD-8663 | biostudies-arrayexpress
MetabolomicsIdentification of Cetobacterium somerae as a key contributor to muscle quality improvement through intestinal microbiota transplantation from faba bean-fed donors in Yellow River carp (Cyprinus carpio)

Background The gut microbiota plays a significant role in modulating the growth and function of host muscle, and microbiota transplantation experiments provide compelling evidence of its capacity to improve muscle quality. Feeding faba beans improves the muscle quality of Yellow River carp. ...

2025-10-13 | MTBLS13128 | MetaboLights
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